|CCL 06.08.20 Pharmacokinetics & Pharmacodynamics for Medicinal Chemists: Achieving Therapeutic Efficacy, Boston, MA|
From: chemistry-request at ccl.net
To: chemistry-request at ccl.net
Date: Wed Feb 1 09:54:44 2006
Subject: 06.08.20 Pharmacokinetics & Pharmacodynamics for Medicinal Chemists: Achieving Therapeutic Efficacy, Boston, MA
Pharmacokinetics & Pharmacodynamics for Medicinal Chemists: Achieving Therapeutic Efficacy AUGUST 20 - 22, 2006 | THE SHERATON BOSTON | BOSTON, MA http://www.chemistry.org/portal/a/c/s/1/acsdisplay.html?DOC=acsprospectives%5c06pharmacokinetics%5cindex.html Conference chairs David Rodrigues of BMS and Scott Obach of Pfizer are putting together a program to explore the range of approaches that can be used to project the exposure and dose necessary to achieve therapeutic efficacy, and the methods that enable improvement of pharmacokinetic (PK) properties. Presentations will cover a variety of topics such as in vitro screening, PK predictions, the conduct of in vivo PK studies, PK-pharmacodynamics, the use of biomarkers, human dose estimates and newer "exploratory IND" strategies. A preliminary agenda and confirmed speakers to date include: Day 1 AM -- In Vitro Approaches (Conference co-chair Scott Obach, session chair) * High-throughput approaches with Daniel Kassel of Takeda San Diego * Metabolic Soft Spots with Michael Fisher of Boehringer-Ingelheim * Microsomal screening methods/IVIVCs with Robert Riley of AstraZeneca UK * Medicinal Chemist's perspective & case histories with Nicholas Meanwell of BMS Day 1 PM -- In Vivo Screening Methods (Scott Grossman of BMS, session chair) * Cassette Dosing and other screens with David Christ of SNC Partners * More detailed in vivo models (e.g. BDC models/discrete PK analyses, etc) with Jiunn Lin of Merck * Medicinal Chemist's perspective/case histories with Phil Carpino of Pfizer Day 2 AM -- PK/PD and Estimating Human Doses (Conference co-chair David Rodrigues, session chair) * PK/PD Basics with Ellen Wang of Pfizer * PK/PD Discovery Applications with Zheng Yang of BMS * Human dose projections and their implications with Richard Morrison of Schering-Plough Day 2 PM -- Exploratory INDs (Scott Grossman of BMS, session chair) * Overview of Exploratory INDs * AMS and other microdose strategies with Steven Tannenbaum of MIT * Biomarkers for dose selection and target validation Closing Comments - Scott Grossman of BMSNOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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