When do discoveries become miracles?

At Pfizer Global Research & Development (PGRD), Pfizer’s visionary discovery and development division and the world’s largest research-based biomedical and pharmaceutical organization, we’re not content waiting to witness the evolution of our industry. Instead, we’re driven by science, building on our current successes and capabilities, playing a critical role in developing the most compelling story of scientific discoveries.

Our emphasis on innovation has brought to market a wide range of ground-breaking medicines, such as Lipitor® (atorvastatin calcium), Zithromax® (AZITHROMYCIN), Viracept® (nelfinavir mesylate), Zoloft® (sertraline hydrochloride), Viagra® (sildenafil citrate), and our newest smoking cessation medicine, Chantix® (varenicline). And, today, with a broad research pipeline that spans many therapeutic areas, we are determined to bring even more cures to the marketplace.

But there is much more work to be done and we can’t do it alone. That’s why we’re always seeking those who share our belief that science can improve our world, that by working together we can bring exciting new therapies to patients on a global scale and forever change the way we improve the health and well-being of all people.

Currently, we are seeking the following:

Computational Chemist (Mid - Sr. Level:  Multiple Opps)

In this role, you will be both a scientific and strategic leader on Research project teams, working closely with synthetic medicinal chemists, biologists and structural biologists, drug metabolism and other project team members to define and achieve project goals. You will have a lead role in data analysis, decision-making and compound design, and will be a major contributor to project teams both in shaping and executing project strategies. In addition to your work on specific projects, you will be a scientific leader with opportunities to advance the science of Pharmaceutical Research by identifying new computational and multidisciplinary approaches that improve Research productivity and success across multiple projects, disease areas, and disciplines.  For qualified candidates, opportunities exist for direct supervision of other computational chemists in addition to your independent contributions to the projects and portfolio.

Therapeutic Area Computational Chemists are focused on the drug discovery phase of Pharmaceutical Research and provide leadership and scholarship on topics such as target analysis, lead identification, lead selection and analog design. These positions involve the application of a wide variety of computational approaches including structure-based design and pharmacophore modeling, library design, virtual screening and lead-hopping, HTS analysis, QSAR and in silico modeling of ADME/Tox. TA Comp Chemists are also involved in the development of new approaches to solve specific or general problems in pharmaceutical research. As an independent researcher and integral member of project teams, as well as a scientific leader, you will have many opportunities to make direct contributions to Pfizer's drug discovery efforts.

The position requires a PhD in computational chemistry or equivalent work experience and 5+ years of relevant industry experience.  The position requires a complete foundation of computational principles and advanced knowledge of multiple approaches for applying computational chemistry to pharmaceutical research projects, including many of those mentioned above, with experience applying them.  Candidates should also have a good working knowledge of many related aspects of drug discovery, such as medicinal chemistry, biology, structural biology, and drug metabolism.  The candidate should also have experience with a wide variety of commercial comp chem software and significant experience using Linux/UNIX.   Knowledge of scripting and programming languages are a plus. Over 2 years of demonstrated experience in supervising computational scientists is required for candidates to be considered for supervisory positions.

To apply for this position, located in Groton, CT, please visit www.pfizer.com/careers and reference requisition number 70081.

Now you can be a vital member of a research and development company unlike any other, Pfizer Global Research & Development. Join us and turn your knowledge into therapies.

To learn more about our people, our products and our plans for the future, visit www.pfizer.com/careers

We’re proud to be an equal opportunity employer and welcome applications from people with different experiences, backgrounds and ethnic origins.