COTI presently has an opportunity for a Senior Scientist who can, in time,
assume the day-to-day responsibility for the development of new predictive 
modelling systems, molecular profiling and selection of drug candidates in 
addition to the identification of new high potential project for COTI and 
its partners.

This position will appeal to a recent graduate from a PhD program in 
molecular biology, pharmacology or medicinal chemistry who is 
intellectually flexible, willing to challenge more traditional methods 
and work at the next frontier of drug discovery. 

This challenging position will require a person with a deep and current 
knowledge of the principles of molecular pharmacology and drug discovery 
coupled with an understanding of computerized statistical modelling 
processes. 

COTI is located in London, Ontario, a centre of excellence in 
South-Western Ontarios medical system. COTI offers competitive 
compensation and in service training opportunities.

If this opportunity appeals to you and you would like to explore the 
possibility of working with COTI, please contact Blake Bexon, 
bbexon**criticaloutcome.com.

COTI respond to all applications that we receive.

Position Description

Position title
Senior Scientist

Reports to
Chief Scientific Officer/President

Responsibilities and Objectives
1.	Develop new modelling systems

        	Add new molecules to the database

        	Add new descriptors to the model

        	Develop a training set for artificial intelligence. 
                Build new predictive models (eg ADME) that are specific 
                for such things as disease,%  absorption, metabolic fate, 
                etc. 

2.	Develop new projects for COTI

        	Work with the Scientific Advisory Board, the Management 
                Committee and the Chief Scientific Officer to identify 
                potential new projects  both for in-house applications 
                as well as custom projects for clients

        	Identify an appropriate target, assemble the requisite 
                drug database and develop a proposal for consideration 
                by customers and/or senior corporate management.

3.	Profile, optimize and select drug candidates

        	Working closely with the Chief Scientific Office, use 
                the computational modelling system to select drug 
                candidates.

4.	Collaborate with  Computer Programmer 

        	Provide guidance and direction to the Computer Programmer 
                using a high level understanding of database structure, 
                querying and intelligent structured database searches.

        	Supervise the creation of a table format that represents 
                the structure of molecules in the database.

        	Provide descriptions of molecules to be evaluated using 
                chemical drawing and editing software.

Skills and Experience 

Essential

Good knowledge of SQL syntax and principles.

Advanced knowledge of molecular pharmacology and drug discovery.

Sound knowledge of computerized statistical modelling processes.

Intellectual flexibility and the willingness to challenge 
traditional methods.

Demonstrated ability as an independent self-motivated worker.

Ability to write clear, concise scientific and business reports.

Preferred

High level understanding of chemical file formats such as SDF, MOLE, 
SMILES, CMX and/or ADF

Ability to use chemical drawing and editing software such as Chemdraw, 
JSISdraw, Casdraw.

Previous experience in a supervisory role.

Knowledge of artificial intelligence

Ability to make public confident and persuasive public presentations.

Ability to write effective grant applications.

  
Send your cover letter, current resume or CV and list of references by 
e-mail to Blake Bexon, bbexon**criticaloutcome.com.