Schrodinger, a technology leader specializing in software solutions for 
life science research and development, is searching for a highly qualified 
person preferably with an MSc to fill a full time position in either our 
downtown Portland, Oregon or our midtown Manhattan offices.  The successful 
candidate will use their knowledge of the detailed acid/base behavior 
of complex organic molecules and their computer skills to extend and 
improve the parameters used by Epik, a program designed to predict pKa 
values and the overall protonation state of drug-like molecules.  

This challenging job involves collecting pKa data and performing ab initio 
quantum calculations, using Jaguar, to generate a solid picture of the 
acid/base behavior for each of a large number of organic functional groups.  
This person will in turn use this data to add to or refit the parameters 
used in Epiks enhanced Hammett and Taft pKa prediction technology.  While 
the position involves working as part of a team of highly trained scientists, 
the abilities to think critically and work independently are equally important.

Job Requirements:
	Add and fit parameters used by Epik  to accurately predict pKa 
            values for more classes of organic functional groups
	Entry of chemical structures and data into databases
	Processing chemical information using advanced scientific software 
            including Jaguar, LigPrep, MacroModel and Maestro
	Critically assess the correctness of the information gathered or generated
	Organize chemical information for long term use
	Write Python scripts to automate processing and testing

Essential Qualifications and Experience:
	Organic chemistry or biochemistry major, preferably at a MSc level
	Solid understanding of organic chemistry as it relates to acid/base behavior
	Ability to interpret and apply a wide range of organic chemistry nomenclature
	Critical reasoning
	Excellent organizational and communication skills
	Ability to work independently yet function well as part of a team
	An aptitude for using computers to solve scientific problems
	Experience or familiarity with the properties of heterocyclic organic molecules 

Desirable Skills:
	Computer scripting languages such as bash and Python
	Experience with Linux and Unix
	Experience with Windows
	Experience with molecular modeling

For consideration, please send CV including publications, thesis topic, 
and adviser information to careers ~~ schrodinger.com.

Benefits include medical and dental coverage, 401(k), flexible spending 
account, a generous vacation policy, and tuition reimbursement.

Schrdinger, Inc. is an equal opportunity employer.