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* Driving back disease
* Enhancing the quality of life
* Producing globally, for the greatest number

Let more people feel the impact of your work with sanofi-aventis. 
World-class research capabilities allow our talented teams to develop
medicines that fight challenging diseases in major therapeutic areas. 
Each year, we invest billions to provide our research and development
personnel with the advanced resources and technology to push the
limits of science. Sanofi-aventis also supports innovation with
research grants to scientists and clinicians throughout the world. 
Ours is the third-leading pharmaceutical group in the world, and we
are proud that our research and development organization ranks among
the very best.  We employ about 16,000 scientific personnel in 20
research centers on three continents, including approximately 2,600 at
our Bridgewater, NJ site.  Are you prepared to help us drive back disease?

We currently seek a Postdoctoral Fellow to be responsible for using
computational chemistry software tools for accelerating library for
different protein targets. The potential candidate is expected to use
various in silico methods for comparison of chemical spaces of
compound collections using novel in-house tools and design of
combinatorial libraries. It is also expected to use ligand-based and
receptor-based approaches to perform virtual screening. The job
involves leveraging all possible in silico technologies for library
design & lead identification and working within a
multidisciplinary team of scientists. The position demands
flexibility, enthusiasm and strong skills to communicate scientific
results to project teams. This is an 18 month position.
 
RESPONSIBILITIES
* Analyzes the chemical space of Tucson combichem collection using
  novel in-house approaches.Evaluates the complementarity of different
  compound collections. Evaluates and prioritizes new library proposals
  based on the knowledge of the existing corporate chemical space.

* Defines the chemical space of known bio-relevant compounds (both
  internal and external) for various targets from multiple databases
  with a view to understand the Bio-relevant chemical space and help in
  directing the design of the new focused libraries with a view to
  improve the library design process with rational and bio-relevant
  input to the design.

* Supports virtual screening initiatives of the drug design group using
  ligand-based and receptor-based modeling tools.

* Implements the scientific project in consultation with the supervisor
  and other teammates. Innovation in scientific projects. No personnel
  decisions.  

* Works closely with other associates in the Tucson drug design group
  & medicinal chemistry groups. Also expected to have professional
  interaction with other drug design groups globally.

REQUIRED
* Ph.D in Computational Chemistry and Molecular Modeling with a minimum
  of 0-1 years experience in computational chemistry and molecular
  modeling software applications.

* Experience in hardware platforms such as Unix and Linux &
  parallel computing on Linux clusters and programming languages such as
  C, C++, Perl, Phython, SVA and other scripting languages is expected. 

* Experience in drug discovery problem solving using in silico tools.

* Demonstrated skills in molecular modeling and computational chemistry
  applied to drug discovery.

* Must possess experience in commercial modeling tools such as MOE,
  Sybyl, Unity, Discovery Studio, Catalyst, Maestro, Macromodel, GOLD,
  Glide, etc.

* Strong communication skills to present the scientific results to
  project teams.

DESIRED
* Background in 3D topological descriptors based model development,
  chemical space analysis, library design & data mining.

* Experience with protein binding site analysis and de novo ligand
  design methods.

For more information and to explore available career opportunities,
please visit us online at:
www.careers.sanofi-aventis.us
Req#: S&MA 10119

Sanofi-aventis is an equal opportunity employer that embraces
diversity to foster positive, innovative thinking that will benefit
people worldwide. Sanofi-aventis is also committed to employing
qualified individuals with disabilities and, where warranted, will
provide reasonable accommodation to applicants as well as its
employees.