The computational chemistry group at Lead Pharma (The Netherlands) 
is seeking a scientist to apply the methods of computational chemistry 
to the discovery of new drugs. These methods may include 
pharmacophore generation and analysis, virtual screening, 
ADME-Tox modelling, QSAR, statistics and general data analysis. 

The candidate should have practical experience with several of these 
methodologies, or deeper expertise in two or more of these areas. The 
scientist may develop tools or methodology for these calculations or for 
the analysis and interpretation of their results. Some experience with 
programming and/or scripting languages is essential. Using these 
techniques, the scientist will work closely with medicinal chemists and 
project teams to design compounds with improved potency, selectivity, 
functional behavior and/or ADME properties. Some knowledge of medicinal 
chemistry is an advantage. Knowledge of statistics and chemoinformatics 
are also important. The candidate must have excellent communication
skills, and must work effectively with scientists from other disciplines.
This project will imply strong interactions with chemists as well as with 
biologists. 

The position is currently available; employment agreement 
as well as compensation will meet European high standards.


Essential Qualifications and Experience:
* Ph.D.or Msc in computational chemistry, organic chemistry, physical
chemistry or biochemistry or a related field
* 2 years of relevant experience in computationally-driven lead discovery
 and optimization
* Experience in at least 3 of the following molecular modeling areas: 
 ligand-based drug design, virtual ligand screening, 
 computationally-driven lead optimization, chemoinformatics
* Experience with commercial modeling tools
* Experience with Linux hardware platforms
* Experience with programming and/or scripting languages such as 
  Perl and Python
* Ability to work independently, while maintaining good communications
 across a team of developers
* Strong verbal and written communication skills to present 
  the scientific results to project teams.

The successful candidate will become part of a 
multidisciplinary drug discovery team working on both collaborative 
projects with pharmaceutical/biotechnology partners and in-house efforts 
to improve and apply drug discovery and development computational methods.


Location

Nijmegen, The Netherlads

About LeadPharma
www.leadpharma.com

Qualified individuals should submit a resume and cover letter via e-mail to 

anna.karawajczyk(_)leadpharma.com