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Date: Tue Mar 29 19:41:26 2016
Subject: 16.03.29 Sr. Scientist - Molecular Simulations, Zymeworks Inc, Vancouver, BC, Canada
Zymeworks is a fast-growing biotechnology company dedicated to the research, 
development and commercialization of best-in-class therapeutic bispecific antibodies and 
antibody drug conjugates for the treatment of cancer and autoimmune diseases. 
Zymeworks is proud to have active collaborations with Merck & Co., Inc., Eli Lilly and Co., 
and Celgene Corporation, and is committed to making a meaningful difference in the lives 
of patients everywhere. Zymeworks has developed some of the most innovative bispecific 
antibodies and antibody drug conjugates in the industry for the treatment of cancers with 
high unmet medical needs.

About the Position:

Zymeworks is seeking a senior scientist with extensive experience developing protein 
modeling algorithms and a proven track record of designing algorithms that have impacted 
the area of computational protein design. The position will report to the Molecular 
Simulations Group Lead at Zymeworks.


- Develop and apply protein engineering and design algorithms with minimal supervision
- Develop, validate and document software that implements protein simulation and 
   optimization methods
- Work closely with the software engineering team to meet software quality requirements
- Collaborate with protein engineering and therapeutic development teams to effectively 
   apply protein engineering and analysis software for lead optimization
- Peer-review and mentor junior members in the team
- Participate in the preparation of patents and publications

Required Qualifications:

- A Ph.D. in Physics, Chemistry, Applied Math, Computer Science or a related field
- A minimum of three years of industrial or relevant post-doctoral experience developing 
   and implementing molecular modeling algorithms.  Industrial experience is strongly 
   preferred.  Areas of interest include, but are not limited to: Molecular dynamics/Monte 
   Carlo simulations, Force field/potential development, Protein structure optimization, Free 
   Energy Simulations, Antibody modelling
- Demonstrated aptitude for developing practical and novel applications of molecular 
   simulations methods for addressing therapeutic protein optimization
- Clearly demonstrated capacity to independently lead development efforts as well as guide 
   activities of others
- Proficient in Python, or other programming languages (C/C++, Fortran)
- Fluent in written and spoken English

Desirable Qualifications:

- Experience optimizing numerically intensive code
- Protein bioinformatics experience, including but not limited to: Prediction of protein 
   properties from sequence data, Extraction of residue co-evolution data from sequence 
   data, Binding target prediction/identification from sequence data
- Experience implementing and applying machine learning methods to protein modeling 
   problems.  Methods of interest include, but are not limited to: clustering methods and 
   other unsupervised learning techniques (ie SOMs, kernel PCA, ICA), regression methods 
   (ie random forest regression, Gaussian process regression), classification methods (ie 
   random forests, SVMs, logistic regression)

Why Work for Us?

Zymeworks employees are passionate, engaged and extremely motivated to succeed. Our 
environment is progressive, collaborative, focused and pragmatic. To learn more about 
Zymeworks Inc. and our current openings, please visit our website at

Compensation is on par with industry standards and commensurate with experience and 
includes an extended benefits plan and participation in the employee stock-option plan.
If you are interested in applying for this position please do so through our online jobs board at: Although we appreciate all applications, due
to the high volume of responses, only those selected for interviews will be contacted.
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