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To: jobs at ccl.net
Date: Wed Mar 8 22:20:27 2017
Subject: 17.03.08 Principal Scientist - Computer-Aided Drug Design (CADD), Roche, Switzerland, Basel-Town, Basel

Principal Scientist - Computer-Aided Drug Design (CADD), Roche, Switzerland, Basel-Town, Basel

Job facts
Location: Switzerland, Basel-Town, Basel
Function: Research
Subfunction: Chemistry
Schedule: Full-time
Job level: Individual Contributor
Job type: Regular Employee
Division: Roche Pharmaceuticals
Posted since: 2017/03/07
Job-ID: 3397801926

As a major element of Roche Pharma Research and Early Development (Roche pRED), the Therapeutic Modalities (TMo) function is responsible for creating innovative drug candidates for all Roche pRED Discovery and Translational areas (DTAs), spanning small molecules, biologics and nucleic acid-based therapeutics. As part of TMo, the Chemical Biology (CB) department focuses on the success of Roche's preclinical pipeline by delivering leading edge science through strong expertise in high-throughput, DNA-encoded and phenotypic cell-based screening platforms, translational protein science, enzymology, biophysics, stem-cell platforms, structural biology, and computer-aided drug discovery (CADD).

As a CADD scientist you will:

  • Be an active member of drug discovery teams and a key contributor to their successes
  • Devise and implement testable hypotheses to formulate medicinal chemistry design strategies and inform biophysics and enzymology driven approaches
  • Integrate experimental data and apply computational approaches to generate knowledge and insights at the molecular level
  • Conduct scientific research in specific molecular modeling or cheminformatics areas applicable to drug discovery
  • Contribute to the overall CADD strategy and play an active part in its implementation
  • Maintain an internal and external scientific presence by authoring significant scientific presentations and publications

Who you are
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
As the ideal candidate, you are highly motivated, possess excellent communication skills, enjoy working in multidisciplinary teams and are fluent in English. You have completed your Ph.D. in medicinal chemistry, computational chemistry, or molecular modeling and also bring the following set of skills and expertise:

  • At least 7 years of experience in the pharmaceutical industry
  • A proven track-record of collaborating closely with medicinal chemistry teams, including significant contributions to inventions and publications
  • Outstanding talent in formulating and articulating clear scientific hypotheses and at leading creative and interactive dialogues with medicinal chemists and other drug discovery scientists
  • Excellent knowledge of medicinal chemistry principles, DMPK principles, disease biology and assay technologies
  • Extensive evidence of creative application of 3D molecular design concepts combined with an intimate understanding of small-molecule conformations and protein-ligand interactions
  • Proficiency in cheminformatics approaches
  • Well-practiced ability to mine data, automate workflows, and implement novel computational tools

Interested applicants should submit a cover letter, a curriculum vitae including publications and references as well as a short description (max. 1 page including, as appropriate, max. 1 figure) outlining how they employed a computational approach to solve a drug discovery related question.

Who we are
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites
The Roche has been headquartered in Basel ever since it was founded in 1896. The Corporate Executive Committee, the Board of Directors and all global functions are located here. Basel is also home to both the Pharmaceuticals and Diagnostics global headquarters, and is one of the most important hubs for the research and development of novel medical solutions worldwide.
Our company was founded on the idea that entrepreneurship and scientific research can improve human health. This approach has allowed us to become the world's largest biotech company, the global leader in oncology, the leading provider of in vitro diagnostics, and a pioneer in personalised healthcare.
Over 11,000 women and men from 101 different countries - with different cultural and professional backgrounds and different ways of thinking - work in Basel and Kaiseraugst alone. It is our joint commitment and ideas that drive our success as a healthcare, doing now what patients need next.

Apply on line:
http://www.roche.com/careers/jobs/jobsearch/job.htm?id=E-3397801926&locale=en&title=Principal+Scientist+%E2%80%93+Computer-Aided+Drug+Design+%28CADD%29

Roche is an equal opportunity employer.



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