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Date: Tue Jul 4 11:25:30 2017
Subject: 17.07.04 Postdoctoral Fellowship in Modeling Comparative Enzyme Inhibition, Concordia University, Montreal, Canada
Postdoctoral Fellowship in Modeling Comparative
Enzyme Inhibition, Concordia University, Montreal, Canada
Concordia University in Montreal, Canada is currently accepting
applications for postdoctoral fellowships valued at $47,500 per year
(plus benefits) for each of two years.
Research Program Title: Modeling Comparative Enzyme Inhibition
Supervisor(s): Gilles H. Peslherbe
Reference Number: 2010
There is mounting experimental evidence that nitric oxide (NO) donors are
promising antiparasitics with GAPDH, a central glycolytic enzyme, as a
key target in parasites that rely on glycolysis for their energy supply.
Effective antiparasitics must selectively inhibit the parasite enzyme but
not the host analog. To complement experimental data and to advance our
research on this important issue, state-of-the-art computational and
theoretical chemistry approaches will be used to fully develop our
understanding of the comparative inhibition of parasite vs human GAPDH.
Specifically, we will probe nitroglycerin docking to P. falciparum, T.
brucei, T. cruzi and human GAPDHs and perform molecular dynamics (MD)
simulations of the docked structures to elucidate differences in drug
binding. Additionally, other NO donors, including GSNO and CysNO, will be
docked onto the GAPDHs to predict their comparative reactivity as
potential drugs. The numerous GAPDH crystal structures in the Protein
Data Bank (PDB) will provide an excellent platform for comparative
computational modeling at the molecular level. The results are expected
to establish a new mechanistic model for GAPDH inhibition and demonstrate
the power of a comparative computational approach in probing biochemical
function and drug design.
Academic Qualifications Required:
PhD in chemistry, biochemistry or biophysics with experience in computer
simulations and quantum chemistry. Expertise with molecular dynamics
software packages desirable.
- Applicants must not currently hold a postdoctoral appointment at
- Priority will be given to postdoctoral fellows who have obtained their
PhD from another university although in exceptional cases Concordia
graduates may be considered
- Applicants must adhere to the postdoctoral fellow eligibility criteria
outlined in Concordia Universitys Postdoctoral Policy
Timeline and Application Process:
Open until the position is filled but no later than September 1, 2017
Fellowship start date:
No later than October 1, 2017
- All documents must be submitted to Cynthia Raso at
( Horizon.Postdocs]-[concordia.ca )
- Please include the reference number with your application
- One to three (1-3) page research statement demonstrating fit with the
program described above
- Current curriculum vitae demonstrating research excellence and a
capacity for leadership in the domain (maximum 5 pages).
- Two letters of reference from academic supervisors or current
employers to be sent via e-mail directly to: Cynthia Raso at
( Horizon.Postdocs]-[concordia.ca )
Concordia University is a vibrant research and teaching environment, with
state-of-the-art research facilities and many research centers. Concordia
is located in Montreal, Canada, a diverse and creative city, often ranked
as offering one of the best quality of living experiences in North
For more information view:
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