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Date: Mon Jul 10 05:20:54 2017
Subject: 17.07.10 PhD scholarship in the modelling of protein structure and interactions, Perth, Australia
The Biomolecular Modelling Group at Curtin University (Perth, Australia)
has a PhD scholarship available in a project aimed at the prediction of new
fungal effector-like proteins. This PhD position is available immediately.

by which microbial pathogens thrive is through the externalisation of
effectors, which are imported into host cells, interfere with their
biological processes and promote disease. The discovery of effectors is of
high importance to agriculture, facilitating the screening of cultivars for
disease resistance; however, this is not a simple process. Fungal effector
proteins exhibit little to no amino acid sequence homology to other known
proteins. There is, however, growing evidence that some types of effector
proteins share similar 3D structures despite having very different amino
acid sequences. This project will shed much necessary light into these
effector proteins through the following specific aims: (1) augment existing
bioinformatics pipelines to predict the 3D structure of fungal protein
effectors from publicly available fungal and plant genome/proteome
datasets; (2) discover new fungal effector-like proteins through searching
for similar 3D structures to known effectors; and (3) discover and
characterise new effector-like proteins through the prediction of their
interactions with target plant proteins. This project will be co-supervised
by Prof. Ricardo Mancera (R.Mancera^-^; School of Biomedical
Sciences and Curtin Institute for Computation) and Dr. James Hane
(James.Hane^-^; Centre for Crop and Disease Management,
Department of Environment & Agriculture) at Curtin University. This project
would suit someone with an undergraduate and/or Masters degree in biology,
bioinformatics, biotechnology, chemistry or related field with demonstrable
experience in bioinformatics and/or molecular modelling.

For this PhD position the student will be required to apply for admission
and enrol at Curtin University ( Curtin is the
largest university in Western Australia and is ranked amongst the top
universities in Australia and within the top 1% in the world. The
Biomolecular Modelling Group, headed by Prof. Ricardo Mancera, is one of
the major users of the newly established Pawsey Supercomputing Centre in
Perth, which houses the fastest supercomputer in the southern hemisphere.
In addition, living in the state capital Perth offers a great lifestyle due
to Western Australias superb weather, beaches and outdoors activities.

Applicants whose academic qualifications were not obtained from an English-
language speaking country will likely need to satisfy English language
requirements by attaining 7.0 in all bands of the IELTS or an overall score
of 94 in the TOEFL (with a minimum of 27 in writing and 24 in other areas).
Only applicants that fulfil these requirements need apply by submitting a
copy of their full CV to Professor Ricardo Mancera
(R.Mancera^-^, including full details of all academic degrees
obtained, research skills and experience, any publications and conference
presentations, and the names of 2-3 referees.

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