|CCL 17.07.10 PhD scholarship in the modelling of protein structure and interactions, Perth, Australia|
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To: jobs at ccl.net
Date: Mon Jul 10 05:20:54 2017
Subject: 17.07.10 PhD scholarship in the modelling of protein structure and interactions, Perth, Australia
The Biomolecular Modelling Group at Curtin University (Perth, Australia) has a PhD scholarship available in a project aimed at the prediction of new fungal effector-like proteins. This PhD position is available immediately. PROJECT: PREDICTION OF NEW FUNGAL EFFECTOR-LIKE PROTEINS. The primary means by which microbial pathogens thrive is through the externalisation of effectors, which are imported into host cells, interfere with their biological processes and promote disease. The discovery of effectors is of high importance to agriculture, facilitating the screening of cultivars for disease resistance; however, this is not a simple process. Fungal effector proteins exhibit little to no amino acid sequence homology to other known proteins. There is, however, growing evidence that some types of effector proteins share similar 3D structures despite having very different amino acid sequences. This project will shed much necessary light into these effector proteins through the following specific aims: (1) augment existing bioinformatics pipelines to predict the 3D structure of fungal protein effectors from publicly available fungal and plant genome/proteome datasets; (2) discover new fungal effector-like proteins through searching for similar 3D structures to known effectors; and (3) discover and characterise new effector-like proteins through the prediction of their interactions with target plant proteins. This project will be co-supervised by Prof. Ricardo Mancera (R.Mancera^-^curtin.edu.au; School of Biomedical Sciences and Curtin Institute for Computation) and Dr. James Hane (James.Hane^-^curtin.edu.au; Centre for Crop and Disease Management, Department of Environment & Agriculture) at Curtin University. This project would suit someone with an undergraduate and/or Masters degree in biology, bioinformatics, biotechnology, chemistry or related field with demonstrable experience in bioinformatics and/or molecular modelling. For this PhD position the student will be required to apply for admission and enrol at Curtin University (http://www.curtin.edu.au). Curtin is the largest university in Western Australia and is ranked amongst the top universities in Australia and within the top 1% in the world. The Biomolecular Modelling Group, headed by Prof. Ricardo Mancera, is one of the major users of the newly established Pawsey Supercomputing Centre in Perth, which houses the fastest supercomputer in the southern hemisphere. In addition, living in the state capital Perth offers a great lifestyle due to Western Australias superb weather, beaches and outdoors activities. Applicants whose academic qualifications were not obtained from an English- language speaking country will likely need to satisfy English language requirements by attaining 7.0 in all bands of the IELTS or an overall score of 94 in the TOEFL (with a minimum of 27 in writing and 24 in other areas). Only applicants that fulfil these requirements need apply by submitting a copy of their full CV to Professor Ricardo Mancera (R.Mancera^-^curtin.edu.au), including full details of all academic degrees obtained, research skills and experience, any publications and conference presentations, and the names of 2-3 referees.NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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