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CCL 18.03.20 Postdoc in Computational biotechnology: Energetics and kinetics of substrate channeling in enzyme cascades, U of Duesseldorf | ||||||||||||
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From: jobs at ccl.net (do not send your application there!!!) To: jobs at ccl.net Date: Tue Mar 20 13:03:20 2018 Subject: 18.03.20 Postdoc in Computational biotechnology: Energetics and kinetics of substrate channeling in enzyme cascades, U of Duesseldorf Applications are invited for a Postdoc position available 1.5.2018 in the Computational Pharmaceutical Chemistry & Molecular Bioinformatics group (Prof. Dr. Holger Gohlke; http://cpclab.uni-duesseldorf.de) at the Heinrich Heine University Duesseldorf, Germany. TOPIC: Computational biotechnology: Energetics and kinetics of substrate channeling in enzyme cascades Background: Multienzymatic cascade reactions, i.e., the combination of several enzymatic transformations in concurrent onepot processes, offer considerable advantages: the demand of time, costs and chemicals for product recovery may be reduced, reversible reactions can be driven to completion and the concentration of harmful or unstable compounds can be kept to a minimum. However, insufficient transfer of intermediates between the individual enzymes / reaction steps has been recognized as a limiting factor. In this project, the energetics and kinetics of substrate channeling in enzyme cascades will be investigated by unbiased and biased molecular dynamics simulations. The aim is to gain reliable predictions on how substrate access to the catalytically active centers in enzyme cascades can be optimized by focused mutations and improved immobilization. In addition, modeling and simulation approaches shall provide important clues for optimizing individual cascade enzymes in terms of stability, substrate specificity, and / or stereoselectivity. The project will be performed in the context of the CLIB (Cluster Industrial Biotechnology; http://www.clib2021.de/) Center of Competence Biotechnology (CKB), which comprises projects located at four Universities around Duesseldorf, addresses the megatrends resource efficiency, crude materials, and health, and generates an integrated infrastructure for bioeconomy in the state of North-Rhine Westphalia (see also here: https://www.land.nrw/de/pressemitteilung/elf-projekte-zum-ausbau-vonforschungseinrichtungen- nordrhein-westfalen-sollen-mit). Requirements: Ideal candidates will have a record of excellence (PhD plus publications in highly visible journals) and a strong background in computational (bio-)chemistry, computational structural biological, molecular simulations, and molecular informatics as well as a high interest in working in an interdisciplinary research field. Detailed information about living and studying in Duesseldorf is provided here: http://www.uni-duesseldorf.de/home/leben-in-duesseldorf.html Applicants should submit applications (a one-page letter of motivation why they are interested in the respective project and how they can contribute to the projects success, a current CV, and contact data of three references) by email to gohlke{=}uni-duesseldorf.de . Please provide all documents as one PDF file.NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!! All @ signs were changed to {=} to fight spam. Before you send e-mail, you need to change {=} to @ For example: change joe{=}big123comp.com to joe@big123comp.com Please let your prospective employer know that you learned about the job from the Computational Chemistry List Job Listing at http://www.ccl.net/jobs. If you are not interested in this particular position yourself, pass it to someone who might be -- some day they may return the favor. |
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