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Date: Sun Jul 8 10:23:00 2018
Subject: 18.07.08 Postdoc in Computational Drug Design


2,5-year Postdoc in Computational Drug Design / Computational Chemistry




The Computational Drug Design Group (Gloriam group), Department of Drug Design and Pharmacology, University of Copenhagen, wishes to employ a 2,5-year postdoc in Computational Drug Design or Computational Chemistry. The position starts 1. October 2018 or soon thereafter (latest Jan 1st) and lasts for 2,5 years.



The Gloriam group ( conducts computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) one of the largest drug target families. The group also heads the GPCR communitys main database and web server, GPCRdb ( serving ~2500 monthly users. The group currently has 15 members, funded mainly by an ERC Starting Grant and Lundbeck Foundation Fellowship, and has in the last two years published in e.g. Nature, Cell, Nature Reviews in Drug Discovery, Nature Chemistry and Nucleic Acids Research.



The project aims to identify and optimise selectivity inhibitors of G proteins that will serve as important probes to dissect receptor signalling pathways and to design drugs/ligands with pathway-selectivity (aka. biased agonism). Most inhibitors will be derived by designing peptides from protein-protein complexes, and increasing their stability and membrane permeability. The project may also include small molecule virtual screening.


The applicant

You have a solid experience in computational drug design / computational chemistry and an interest in scripting. You are motivated by working in interdisciplinary project teams, identifying ligands/probes to increase our understanding of human biology, and solving challenging problems by independently and quickly learning new knowledge, techniques and correlations. You are a good team player, and will have the opportunity to work together with experienced computational drug designers; as well as to supervise students.


Qualification requirements

Mandatory requirements

       A PhD in computational chemistry or similar topic

       Experience of computational ligand identification and optimisation

       Some experience of scripting/programming

       Demonstrated ability to independently learn new concepts and solve biological problems

       Fluency in English and demonstrated ability to write scientific texts

Additional meriting qualifications

Experience of, and skills in:

       G protein-coupled receptors

       The Schrdinger Drug Discovery Suite and PyMOL

       Shell scripting, programming in Python or other languages

       Machine learning

       Protein sequence analysis



Key criteria for the assessment of applicants

The key criteria will be the strength of the applicants CV.

       Professional qualifications relevant to the project

       Relevant work experience


       Other professional activities

       Language skills

       Good interpersonal skills 


General job description

Your key tasks as a Post Doctorial fellow at the Faculty are to:

       Manage and carry through your research project

       Write scientific articles

       Participate in the education and guidance of students


Terms of employment

The post will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure.



For further information about the post, please contact Associate Professor and Group Leader David E. Gloriam via or (+45) 93 56 54 49.



The application, in English, must be submitted in the online application form at The application must include the following appendices:

Appendix 1: curriculum vitae with documentation of education.

Appendix 2: a complete list of publications and list of submitted appendices.

Appendix 3: documentation of additional research qualifications.


In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. No research/project plan needs to be submitted. Following processing of the application, any application material sent will be destroyed.


The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008.

University of Copenhagen and Denmark
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at and

Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at


Deadline: 15-08-2018
Employer: University of Copenhagen



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Modified: Sun Jul 8 14:23:02 2018 GMT
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