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Date: Wed Sep 5 11:49:10 2018
Subject: 18.09.05 Associate Principal Scientist, Computational Chemistry, AstraZeneca, Sweden

Associate Principal Scientist, Computational Chemistry, AstraZeneca, Sweden

Location: Gothenburg, Västra Götaland County, Sweden
Job reference: R-034910
Posted date: Aug. 31, 2018

Do you have expertise in Computational Chemistry? Would you like to join a world leading team that push the boundaries of science to deliver life-changing medicines? Then you might be the one we are looking for!

AstraZeneca R&D, Gothenburg, Sweden seek to recruit an Associate Principal Scientist, Computational Chemistry, in the area of Cardiovascular, Renal and Metabolic Diseases (CVRM).

The Innovative Medicines (IMED) Biotech Unit of Cardiovascular, Renal and Metabolic Diseases (CVRM) is one of AstraZeneca's core therapy areas. We push the boundaries of science to deliver life-changing medicines to patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease. To realize our ambitions we stay agnostic to molecular modality.

We drive our pipeline and the areas of scientific leadership to a large extent in collaborations with world experts which provides you as a scientist with the unique opportunity to access the most advanced knowledge and opportunities to stay at the fore-front of science.

The Medicinal Chemistry Department within the CVRM IMED is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets.

The role

The Computational Chemistry team leads efforts to expand the use of state of the art in silico methods for modelling, ligand design, property predictions and data analysis supporting the CVRM drug discovery projects. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Sciences departments to advance the CVRM project pipeline.

As a Computational Chemist you will have a profound impact on multiple projects across the CVRM portfolio with a focus on target identification, lead generation and lead optimization including New Modalities such as Peptides, Macrocycles or Oligonucleotides. You will have a key role in modelling, analysis of large datasets, drug design, and contribute to our CADD strategy including build of our future AI platform. The role holder will also provide discipline based scientific leadership and represent the department and AstraZeneca at interdisciplinary meetings and conferences, both internally and externally.

Major Duties and Responsibilities

  • Impact simultaneously multiple discovery projects by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches.
  • The work will include helping project teams analyze, interpret, and visualize biological data, and the communication of results within project teams and departments.
  • With excellent knowledge of modern computational chemistry, the candidate will identify and drive areas of scientific improvements for computational chemistry
  • The candidate will be expected to plan, write and publish high quality scientific papers.

Essential Requirements

We are seeking a drug hunter with a PhD (or equivalent experience) in computational chemistry, biophysics, or a related field with industry experience who would like to join our fast-pace multidisciplinary CVRM computational chemistry team. The candidate is expected to have a high degree of independence and a proven record of excellence in a number of computer-aided drug design techniques to assist in target identification and advancement of discovery programs.

  • Solid knowledge of computational chemistry and medicinal chemistry concepts

  • Expertise in using and improving computational chemistry software as well as knowledge in scientific computing, and programming skills (e.g. Python, Perl, C, C++, Java)
  • Expertise in using chemoinformatics techniques
  • Experience of non-target based strategies (e.g. phenotypic screens) and or experience of computational chemistry applied on peptides, macrocycles or nucleotides will be seen as an advantage
  • A good awareness of Machine Learning approaches
  • Very good written and verbal communication skills

If you are interested, apply on line at
https://job-search.astrazeneca.com/job/gothenburg/associate-principal-scientist-computational-chemistry/7684/9170778

For more information please contact: Dr. Anders Hogner, Medicinal Chemistry, IMED CVRM, Anders.Hogner++astrazeneca.com

Welcome with your application no later than September 30, 2018. AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the worlds most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.



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