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Up Directory CCL 18.09.18 Computational Structural Biologist, ProteinQure, Toronto, Canada
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Date: Tue Sep 18 16:13:23 2018
Subject: 18.09.18 Computational Structural Biologist, ProteinQure, Toronto, Canada

About Us

ProteinQure ( is building the next generation of computational tools to aid in early-stage drug discovery. We're using a combination of biophysical modelling (molecular simulations, knowledge-based methods) and new statistical algorithms (quantum computing algorithms, machine learning) to accelerate protein design. We're working with industry and academic labs to pair these tools with experimental approaches to reimagine how therapeutics are discovered.

We've built a team defined by courage and determination. It doesn't matter whether you are inventing molecular machine learning architectures, reimagining life science partnerships, or designing cutting-edge experiments; working with us involves having the courage to reinvent the status quo and the determination to see it through. We're looking for a Computational Structural Biologist to join our team in Toronto (Canada) to help us apply our technologies for exciting challenges in the field.

About You

You're a scientist or engineer driven to confront challenging unsolved problems by leveraging the world's most cutting-edge technologies. You're comfortable working in a start-up and excel in a fast-paced environment. You are interested in exploring how to integrate human-expertise and computational tools to design new chemical entities.

  • Lead computational drug discovery projects using ProteinQure's protein design platform.
    • Develop protocols for analyzing the protein structure and dynamics
    • Interact with CROs and experimental partners to assist in integrative modelling and experimental validation efforts
  • Perform research of protein design protocols and prepare reports and presentations to guide software and algorithm development
  • Publish scientific articles on protein design methodology and applications
  • Work side-by-side with chemists, biologists, computer scientists, and software developers to develop novel methods for protein design
Nice to haves
  • Peer-reviewed publications on protein-protein interactions, protein engineering, design, and/or structure and function
  • Confidence with molecular modelling and visualization software (Rosetta, Maestro, MOE, PyMol, Chimera, VMD)
  • Experience with molecular simulation software (OpenMM, GROMACS, AMBER, NAMD, etc.) and enhanced-sampling methods (REMD, Metadynamics, GaMD, etc.)
  • Experience working with data from biophysical experiments (NMR, EPR, FRET, X-ray crystallography, etc.) or measuring protein-protein interactions (display technologies)
  • Familiarity with structural data formats (PDB, trajectory) and analysis using Python libraries
  • PhD in Biochemistry, Bioinformatics, Chemistry or related field
  • Scripting and data analysis experience using Python
  • Excellent communication skills, comfortable explaining technical concepts to a diverse audience
  • A competitive mix of equity and salary
  • Unlimited vacation
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