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Date: Mon Sep 24 10:37:29 2018
Subject: 18.09.24 Associate Principal Scientist - Computational Chemistry, IMED RIA, AstraZeneca, Sweden

Associate Principal Scientist - Computational Chemistry, IMED RIA, AstraZeneca, Sweden

Position: Full time
Job Id: R-029964
Location: Sweden - Gothenburg

Do you want to join a world leading team in developing the next generation of respiratory medicines?
Respiratory is one of AstraZeneca's main therapy areas. Our aim is to transform asthma and COPD treatment through inhaled combinations at the core of care, biologics for the unmet needs of specific patient populations, and scientific advancements in disease modification.
To further strengthen our expertise and capacity we are now recruiting a world-class Scientist within Computational Chemistry.

AstraZeneca is committed to the development of the next generation of innovative respiratory medicines. The Computational Chemistry team leads efforts to expand the use of state of the art in silico methods for modelling, ligand design, property predictions and data analysis supporting the RIA drug discovery projects focused on small to medium-sized molecules. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Sciences departments to advance the RIA project pipeline.

Main Duties and Responsibilities
In this role, you will have a profound impact on multiple projects across the RIA portfolio, with a focus on target identification, lead generation and lead optimization. Your particular focus will be structure-based design and simulations.
You will have a key role in modelling and analysis of large datasets and drug design. You will be a significant contributor to project progression and a project team member. Furthermore, you will also provide discipline based scientific leadership and represent the department and AstraZeneca at interdisciplinary meetings and conferences, both internally and externally.

Accountabilities and responsibilities:

  • Deliver profound expertise in structure-based drug design projects
  • Simultaneously impact multiple discovery projects by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches
  • Analyze, interpret and visualize biological data and communicate results within project teams and departments
  • Identify and drive areas of scientific improvements for computational chemistry
  • Plan, compose and publish high quality scientific papers

Essential Requirements
We are looking for a senior computational chemist, motivated to join our dynamic multidisciplinary team. You are expected to have a high degree of independence and to act as an authority in a number techniques, to assist target identification and advancement of discovery programs.

  • PhD (or equivalent experience) in computational chemistry, chemistry, pharmacology or a related field
  • Strong computational background and excellent knowledge of modern computational chemistry
  • chemistry and medicinal chemistry concepts
  • Expertise in using computational chemistry software as well as knowledge in scientific computing, and programming skills (e.g. Python, Perl, C, C++, Java)
  • Experience from drug discovery teams with a track record of working in drug design projects
  • Profound expertise in structure-based drug design and biophysical methods
  • Excellent written and verbal communication skills
  • Industry experience preferred

If you are interested, apply now at:

For more information about this position please contact: Dr. Christian Tyrchan: Christian.Tyrchan .

Welcome with your application no later than October 29th, 2018

Our Respiratory research is mainly carried out at the vibrant AstraZeneca Research site in Gothenburg, Sweden. However, collaboration is a way of life for us. Extensive collaboration with our AstraZeneca colleagues in Cambridge UK, the MedImmune research units in Gaithersburg and Cambridge, as well as numerous academic institutions and partners around the globe gives us access to a worldwide network of expertise and innovation.

Our external collaborators expand both academic and biotech organisations including Imperial College London, Pieris, Bicycle Therapeutics, Ethris and many more. We aim to be flexible, responsive, open and honest and look for people, companies and investigators who share our collaborative spirit and high scientific standards.

AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Respiratory, Inflammation & Autoimmunity (RIA) unit is one of AstraZenecas core therapy areas focused on the discovery and development of novel treatments for respiratory diseases.

About Us
AstraZeneca is an exciting global, innovation-driven biopharmaceutical company. We're inspired by what science can do. Driven by the desire to meet unmet patient needs in our core therapeutic areas. Bold in our thinking. Proactive in pursuing discoveries beyond imagination. At sites across the world, we bring teams together in a spirit of collaboration to turn great ideas into life-changing medicines – strengthening our product portfolio and harnessing the potential of a pipeline across all stages of the drug development process.
You'll be part of a team that's rolling back the frontiers of science to turn yesterday's impossible into the normal of tomorrow. So, if you share our focus and passion, join us and make a difference to patients – and in return, we'll help you develop way beyond what you thought possible.

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