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Up Directory CCL 19.01.08 Computational Chemist,Xtalpi,ShenZhen, China
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To: jobs at ccl.net
Date: Wed Jan 9 02:27:08 2019
Subject: 19.01.08 Computational Chemist,Xtalpi,ShenZhen, China

XtalPi is a pharmaceutical technology company that is reinventing the industry's approach to drug research and development with its Intelligent Digital Drug Discovery and Development (ID4) platform.
With tightly interwoven quantum physics, artificial intelligence, and high-performance cloud computing algorithms, XtalPi's ID4 platform provides accurate predictions on the physiochemical and pharmaceutical properties of small-molecule candidates for drug design, solid-form selection, and other critical aspects of drug development. XtalPi is dedicated to improving the efficiency, accuracy,and success rate of drug research and development, and contributing to a healthier society worldwide.

Founded in 2014 by a group of quantum physicists at MIT, XtalPi has since built an elite team with multi-disciplinary expertise in physics, chemistry, pharmaceutical R&D, and algorithm design.XtalPi's cutting-edge technologies, innovative solutions, and diverse applications across the pharmaceutical value chain have helped it gain industry approval and establish strategic partnerships with top international pharmaceutical companies.

We are looking for some computational chemists with experience in computational chemistry or drug development,who are good at CADD/AIDD .You will work with XtalPi's other scientists to develop drug design algorithms.
You will work in XtalPi's R&D headquarters,based in ShenZhen. ShenZhen has livable environment and various talent award policies.

Senior Computational Chemist (CADD)
Responsibilities:
*Analyze, curate and automate the processing of the pharmaceutical molecule database.
*Help to develop the algorithms and software for drug-like property and binding affinity predictions.
*Establish the prediction protocol and analyze the results for further algorithm improvement.

Requred qualifications:
*Ph.D. in chemistry, biology, pharmaceutics or related field.
*Extensive knowledge and experience in QM simulation and QSAR.
*Strong programming skills and a minimum of 3-year programming experience.
*Good multidisciplinary team working and communication skills.
*Comfortable on working under Linux OS.

Desirable/Preferred qualifications:
*Experience with cheminformatics or various analysis of pharmaceutical molecule database.
*Experience with QM methodology development.
*Experience with molecular simulations using empirical force field.
*Experience with property prediction with statistical mechanics.
*Experience with experimental studies in medicinal chemistry.

Senior Scientist for Crystal Structure Prediction
Responsibilities:
*Develop algorithms and software in predicting crystal structures of drug molecules.
*Develop and further improve global searching algorithms.
*Build AI models for crystal structure prediction and crystallization.

Requred qualifications:
*Ph.D. or Master Degree in computational chemistry, physics, material or related field.
*Extensive knowledge and experience in studies using/developing global optimization, conformation search or crystal packing algorithms.
*Good programming skills and a minimum of 3-year programming experience.
*Good multidisciplinary team working and communication skills.
*Comfortable on working under Linux OS.

Desirable/Preferred qualifications:
*Experience with molecular modeling or simulation using empirical force field or QM.
*Experience in organic chemistry, pharmaceutical chemistry.
*Knowledge of basic crystallography or space groups.

Computational Scientist, Artificial intelligence and computational chemistry
Responsibilities:
*Develop computational approaches to predict biological activity of small molecules/peptides/antibody utilizing machine learning, MD/FEP and other methods.
*Develop models and algorithms for drug discovery.
*Collaborate with interdisciplinary talents to drive effective decision-making through candidate nomination using high-content and time-resolved screening data.
*Investigate scientific literature to integrate biological insights into lead characterization and screening efforts.

Requred qualifications:
*Advanced degrees in computational chemistry, computational biology, computational chemical biology, computer science, biochemistry, bioengineering, bioinformatics or related field. Ph.D. is strongly preferred.
Candidates with extensive computational experience are also encouraged to apply.
*3+ years of experience with computational drug discovery (e.g., structure-based and ligand-based drug design, FEP, TI etc.). Industrial experience is a plus.
*Experience with machine learning (familiar with statistical models, machine learning models) and tools, such as scikit-learn, tensorflow, etc.
*Programming skills in Python, C/C++, R, Matlab or Bash.
*Good writing and communication skills.

How to apply: Please email your CV and cover letter to cv]|[xtalpi.com.
You will work in XtalPi's R&D headquarters,based in ShenZhen. ShenZhen has livable environment and various talent award policies.
We look forward to your application! NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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Modified: Wed Jan 9 07:27:08 2019 GMT
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