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Up Directory CCL 19.02.06 Postdoctoral Research Fellow Molecular Machine Learning (West Point, PA)
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Date: Wed Feb 6 20:50:28 2019
Subject: 19.02.06 Postdoctoral Research Fellow Molecular Machine Learning (West Point, PA)
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United 
States and Canada, is a global health care leader with a diversified 
portfolio of prescription medicines, vaccines and animal health 
products. The difference between potential and achievement lies in the 
spark that fuels innovation and inventiveness; this is the space where 
Merck has codified its legacy for over a century. Mercks success is 
backed by ethical integrity, forward momentum, and an inspiring 
mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the worlds 
premier, most research-intensive biopharmaceutical company. Today, 
were doubling down on this goal. Merck Research Laboratories is a 
true scientific research facility of tomorrow, and will take Mercks 
leading discovery capabilities and world-class small molecule and 
biologics R&D expertise to create breakthrough science that radically 
changes the way we approach serious diseases. 

Be a part of the legacy: MRL Postdoctoral Research Fellow Program

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow 
Program aims to be a best-in-industry program for industrial 
postdoctoral researchers, designed to provide you with an academic 
focus in a commercial environment. With the resources, reach, and 
expertise of a large pharmaceutical company, postdoctoral researchers 
will be positioned to excel in an institution committed to breakthrough 
innovation in research and discovery.

The position will be in the Computational and Structural Chemistry 
group, based in West Point, PA. The successful candidate will develop 
and apply novel machine learning methods on small molecules and 
peptides. This work will improve our ability to design breakthrough 
medicines across therapeutic areas by developing state-of-the-art 
methods for activity and property prediction, and for molecular design.

Responsibilities include but are not limited to:

Design and implementation of machine learning models and workflows, 
both discriminative and generative, in Python.
Assessment of publicly available and internally built predictive 
models: design of metrics and validation techniques, and comparison of 
methods performance.
Application of existing and newly designed models to predict 
properties of small molecules and peptides: 
feature engineering/learning, architecture design and evolution.
Assessment and design of methods to maximize generalizable learning 
from small amounts of data.
Design, implementation, and assessment of generative models to design 
new molecules with specified activity profiles.

Education Minimum Requirement: 

A PhD in Chemistry, Chemical Biology, Biology, Bioinformatics, 
Computational Biology, Pharmacology, Computer Science, Machine 
Learning, or a related field with less than (3) years of postdoctoral 
experience OR graduating with a PhD by summer of 2019. 

Required Experience and Skills: 

Programming experience with high-level (Python, R, Matlab) or low-level
(C, Java) languages.
Demonstrated proficiency in data-mining, statistical modeling, or 
related methods.
Self-motivated, able to independently learn, innovate, and be rigorous.

Preferred Experience and Skills:
Python coding experience. Familiarity with SQL, Pipeline Pilot, Unix.
Experience with deep learning techniques and packages (Pytorch, 
Familiarity with application of cheminformatics methods (QSAR models, 
ADMET prediction, library design).
Statistics, calculus, and organic chemistry fluency.
Track record of innovative research combining methods from multiple 
disciplines to solve complex problems. Strong history of publication 
in peer-reviewed journals.

Your role at Merck is integral to helping the world meet new 
breakthroughs that affect generations to come, and were counting on 
your skills and inventiveness to help make meaningful contributions to 
global medical advancement. At Merck, were inventing for life. 


If you need assistance and/or a reasonable accommodation due to a 
disability during the application or the recruiting process, please 
send a request to staffingaadar|-|


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search 
firms for this employment opportunity.  Please, no phone calls or 
emails.  All resumes submitted by search firms to any employee at 
Merck via email, the Internet or in any form and/or method without a 
valid written search agreement in place for this position will be 
deemed the sole property of Merck.  No fee will be paid in the event 
the candidate is hired by Merck as a result of the referral or through 
other means.

Merck is an equal opportunity employer, 
Minority/Female/Disability/Veteran  proudly embracing diversity in 
all of its manifestations.
All applicants must apply directly online at:
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Modified: Thu Feb 7 01:50:28 2019 GMT
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