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Up Directory CCL 19.07.08 Postdoctoral Opening, Multi-State Protein Modeling - Keedy Lab, NYC
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To: jobs at ccl.net
Date: Mon Jul 8 13:01:38 2019
Subject: 19.07.08 Postdoctoral Opening, Multi-State Protein Modeling - Keedy Lab, NYC
The Daniel Keedy Lab at the CUNY Advanced Science Research Center in New York City 
has an available position for a Postdoctoral Researcher, funded by the National Institutes
of Health.  

The Keedy Lab aims to elucidate the conformational ensembles of proteins and to 
understand how they are shifted by perturbations, including mutations, protein:protein 
interactions, and ligands, to control function.  We are especially interested in how hidden
conformational ensembles drive differences in allosteric regulatory mechanisms for 
protein tyrosine phosphatases (PTPs), which are under-studied but biologically critical.  
To explore these questions, we are developing new multi-state modeling algorithms that 
exploit series of X-ray crystallographic datasets related by temperature, pressure, etc. 
to reveal particular conformational states and the transitions between them.  We are 
also interested in marrying such approaches with rational multi-state computational 
design to engineer proteins with novel allosteric functionalities.

The CUNY Advanced Science Research Center is a new cutting-edge research 
institution located in upper Manhattan in New York City -- the "greatest city in the world".  
The Structural Biology Initiative of the ASRC features seven tenure-track and 
research-track faculty members, pursuing diverse research problems using X-ray 
diffraction, cryo-EM, NMR, mass spectrometry, solution biophysics, and advanced 
microscopy.  The ASRC has shared access to the CUNY High-Performance Computing 
Center, and will also enjoy a new dedicated high-performance computing cluster 
equipped with GPU nodes starting this fall.  The ASRC is also immediately adjacent to 
the New York Structural Biology Center, a consortium of CUNY and eight other New York 
academic institutions with world-class facilities, and 70 miles from Brookhaven National 
Laboratory, featuring the newly constructed National Synchrotron Light Source II, now 
the brightest synchrotron light source in the United States.  

For more information, visit our newly designed lab website: https://keedylab.org

Candidates should have expertise in computational biophysics or related areas.  
Experience writing or contributing to scientific software is significantly preferred.  
Experience with either computational of experimental aspects of crystallography is 
preferred but not required.  This position is available starting immediately, though the 
start date is flexible.

To apply, please contact Dr. Keedy directly at daniel.keedy*asrc.cuny.edu with a CV 
and brief description of your interests.  You may also officially apply to a position in the 
lab here:

https://cuny.jobs/new-york-ny/research-associate-structural-biology-initiative/3F61F1DE234B4BF7BA9E5777089B982C/job/

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