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Date: Tue Oct 1 10:43:21 2019
Subject: 19.10.01 Open PhD and Postdoc positions for the project "Macromolecular Structures from Single Molecule X-Ray Diffraction Experiments"
The Max Planck Institute for Biophysical Chemistry is one of the largest 
institutes of the  Max Planck Society for the Advancement of Science and 
conducts basic research to advance  knowledge and benefit society. 
Innovative projects and interdisciplinary cooperation characterize research 
within the Max Planck Society.  

The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut
Grubmuller) invites  applications for a position as PhD Student or Postdoc 
(f/m/d)(Code Number 26-19) for the project 

"Macromolecular Structures from Single Molecule X-Ray Diffraction Experiments" 

to advance methods to extract high resolution structure information from 
single molecule X-ray diffraction data. In these diffract and destroy 
experiments, femtosecond X-ray free electron laser pulses are shot at a 
single molecule, and the diffraction pattern is recorded. Depending on 
sample size, only very few photons are scattered in each shot, such that
many scattering images have to be combined. 

The analysis is complicated by the fact that for each shot
the orientation of the sample molecule is random and unknown. We have 
recently shown that as few as three recorded photons per image suffice. 
Using recent experimental data, you will develop, implement, and test a 
rigorous Bayesian approach, which holds the promise to drastically reduce 
the number of required photons, thus rendering single molecule X-ray 
structure determination feasible.  

Please refer to our corresponding publication for further details: 

The successful candidate for either position has a keen interest and strong 
skills in theoretical and  computational physics, mathematics, and 
probability theory and a strong interest in interdisciplinary collaborative 

PhD candidates hold (or expect to complete soon) a Masters or equivalent 
degree; Postdocs hold a  PhD or equivalent degree in any of these or a 
related field.  

PhD students will have the opportunity to participate in one of several 
available PhD programs, with  three years funding and a possibility of 
extension, in collaboration with the University of Gottingen.  Masters 
students aiming at a fast track PhD are also welcome. The Postdoc 
position is limited to two  years with a possibility of extension.  

Payment and benefits are based on the TVD (German collective wage 
agreement for the public sector) guidelines. The starting date is 
The group language is English, so no German language skills are required 
but its a great opportunity for you to learn German!
The Max Planck Society is committed to increasing the number of individuals 
with disabilities in its  workforce and therefore encourages applications 
from such qualified individuals. 

Interested? Submit your application with reference to code number 26-19 
including cover letter (explaining background and motivation),  CV, 
transcripts, and publication record preferably via email as one single 
PDF file to: 

Max Planck Institute for Biophysical Chemistry  
Department of Theoretical and Computational Biophysics  
Prof. Dr. Helmut Grubmuller  
Am Fassberg 11  
37077 Gottingen  
Phone:  +49 551 201-2316 
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