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Up Directory CCL 19.10.16 Principal Scientist and Group Lead, Molecular Simulations
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Date: Wed Oct 16 17:29:43 2019
Subject: 19.10.16 Principal Scientist and Group Lead, Molecular Simulations
Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery,
development and commercialization of next-generation bispecific and multifunctional 
biotherapeutics.  Zymeworks suite of complementary therapeutic platforms and its 
fully-integrated drug development engine provide the flexibility and compatibility to 
precisely engineer and develop highly-differentiated product candidates.

Zymeworks is seeking a highly-motivated professional who is looking to grow their 
career with our company. 

This position will report to the Vice President, Technology and will be based in 
Vancouver, BC.

Key Responsibilities

- Plans, schedules and conducts research projects towards new computational 
modeling and simulation products, processes or methods for therapeutic 
biomolecular engineering.
- Collaborates with Software Development, Protein Engineering and Translational 
Research groups to prioritize development needs and manage execution of agreed 
development plans.
- Provides leadership and direction to the molecular simulations development and 
application team. Actively plans and incorporates ML and AI techniques in the 
computational workflow.
- Recruits, supervises and trains staff. Plans, schedules, allocates and prioritizes 
workload to meet operating requirements. Monitors and evaluates performance 
ensuring requirements are met.
- Provides scientific advice to project team members within the company. 
Participates in R&D planning. Prepares and presents reports to management and 
makes recommendations for further investigation.
- Creates, implements and improves existing systems and procedures to increase 
efficiencies and coordination between collaborating parties. Designs and establishes 
standard operating procedures and ensures adherence to best practices. 
- Participates in industry activities, conferences and professional research 
meetings and contributes to technical journals.
- Prepares and presents results to external collaborators and manages interactions
 with external scientific teams.
- Maintains an awareness of new technologies, trends and developments in order 
to improve service and create efficiencies within the department. Keeps up-to-date 
with relevant professional literature and participates in seminars and training 
workshops as required.
- Leads evaluation and screening of externally developed tools prior to internal 
- Fosters effective and collaborative working relationships with fellow employees, 
management and external partners.

Qualifications and Experience

- PhD in a relevant scientific discipline (Computational Chemistry, Biophysics or 
equivalent) and a minimum of 8+ years related experience (may include post-
doctoral experience) or an equivalent combination of education and experience.  
Experience working in industrial scientific software development setting with a 
portion of it in a managerial role. 
- Proven interpersonal skills with the ability to work collaboratively as a member 
of cross-functional team. Ability to establish and maintain effective working 
- Experience applying computational methods in protein modeling. Areas of 
knowledge include: molecular dynamics simulation, multiscale modeling methods, 
enhanced sampling techniques, Monte Carlo simulation, force field development, 
free energy computation, structure optimization, protein bioinformatics, statistical 
mechanics and machine learning
- Experience developing and implementing molecular modeling algorithms or 
numerical simulation algorithms to interrogate biomolecules.
- Proven experience applying machine learning approaches for data mining and 
knowledge driven protein modeling and optimization.     
- Hands on experience and deep understanding of structure guided drug design 
and protein engineering for biologics optimization.
- Experience and understanding of antibody structure, biology and optimization 
would be a plus.
- Ability to lead through example and to establish an environment fostering 
effective and collaborative working relationships.
- Good organizational skills and the ability to work effectively in a high paced, 
fast changing environment. Results-oriented.
- Coding experience in high level language (e.g. C, C++, Java or FORTRAN).
- Coding experience in scripting language (e.g. Python, Perl or Ruby).
- Demonstrated experience leading teams of scientists on method development 

Why Work for Us?

Zymeworks employees are passionate, engaged and extremely motivated to succeed.  
We are excited by the cutting-edge science and technology, the endless possibilities 
this union holds and the sheer opportunity to be a part of something big.  To learn 
more about Zymeworks Inc. and our current openings, please visit our website at 

We offer challenging career opportunities, competitive benefits and an environment 
that recognizes and rewards performance.
If you are interested in this challenging opportunity, please apply online at  Due to the high volume of 
applicants, only those selected for interviews will be contacted.
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Modified: Wed Oct 16 21:29:43 2019 GMT
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