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Date: Wed Oct 23 06:40:39 2019
Subject: 19.10.23 PhD position in structure-based drug design in Bergen / Norway
At the Faculty of Medicine, Department of Biomedicine in the group of 
Professor Ruth Brenk ( ), a PhD-position (100 %)
is available for a period of four years.  

The position is part of the project RESPONsible early Digital Drug 
Discovery  RESPOND3: Towards better computational approaches and 
responsible innovation strategies in early drug discovery: application to 
antibiotics and COPD financed by The Research Council of Norway.

The RESPOND3 project is part of the Centre for Digital Life Norway 
( and is a cross disciplinary collaboration
between research groups at the Centre for Advanced studies in Biomedical
Innovation Law at the University of Copenhagen, the Department of Computing,
Mathematics and Physics at the Western Norway University of Applied Sciences,
the Department of Biomedicine at the Faculty of Medicine and at the 
Department of Chemistry at the Faculty of Mathematics and Natural Sciences 
at the University of Bergen. In total, the team will be composed of 4 
postdocs, 3 PhD students and five principle investigators covering 
medicinal chemistry, computational chemistry and biology, structural 
biology, mathematics, and law. The main focus of RESPOND3 will be hit and 
lead optimization for targets for antibiotics (SAM riboswitch) and chronic
obstructive pulmonary disease (proteinase 3) guided by the use of 
computational methods as well as the development of new scoring functions 
using machine learning. The entire project is embedded in a responsible 
research and innovation strategy.

The main objectives for the advertised PhD position are
- to derive data sets for the development of new scoring functions for 
  protein-ligand interactions with machine learning methods
- to retro- and prospectively evaluate the derived scoring functions
- to design ligands with improved affinities for the targets in the 
  RESPOND3 project
- to supervise master students
This PhD project will be conducted in collaboration with the group of 
Matthias Rarey at the Center for Bioinformatics of University of Hamburg
(Germany) implying that this position will involve short research stays in
his lab.
More details about the position and instructions on how to apply can be found
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