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Date: Thu Nov 7 11:26:43 2019
Subject: 19.11.07 Associate Principal Scientist -- Computational Chemist for New Modality Design, AstraZeneca, Sweden

Associate Principal Scientist -- Computational Chemist for New Modality Design, AstraZeneca, Sweden

Location: Gothenburg, Västra Götaland County, Sweden
Job ID: R-064335
Date posted: 10/28/2019

Are you an experienced Computational Chemist with expertise in Oligonucleotide design? We are recruiting a New Modality Design authority and want you to join us!

Our New Modalities (NMs) Chemistry team leads the efforts focused on growing the use of novel peptide and oligonucleotide-based modalities and molecular conjugates. We are committed to the development of next generation innovative medicines within Respiratory, Inflammation & Autoimmunity (RIA). To achieve this, we collaborate with scientists with diverse expert areas across departments all joined by the goal to discover the respiratory medicines of the future. We are be based at our dynamic R&D site in Gothenburg, Sweden.

Main duties and responsibilities
In this role, you are a part of a team of computational scientists specialized on the design of both small molecules and NMs based therapeutics. You will work at the interface of Computational Chemistry, Chemo- and Bioinformatics for designing new drug modalities, with focus on oligonucleotides.
Your responsibilities will include:

  • Perform molecular dynamics simulations in the field of NMs -- with a special focus on oligonucleotide structure and dynamics
  • Contribute to oligonucleotide sequence design, demonstrating state of the art oligonucleotide design by e.g. identifying and correlating sequence and potency parameters for optimization
  • Seamless collaboration with bioinformatics authorities in:
    • Analysis of mRNA/microRNA target sites for ASOs/siRNAs/antimiRs
    • Identification of suitable mRNA sequence regions for RNAi and generation of RNAi oligonucleotide libraries
  • Positively impact our scientific reputation by identifying and progressing publication opportunities internally, across AZ and together with external partners

Essential Requirements

  • PhD in Computational or Bioorganic Chemistry, Bioinformatics or other related field
  • Expert user of molecular mechanics modeling software for e.g. prediction of binding energies or folding analysis
  • Consistent track record of applied molecular dynamics
  • Strong programming skills are a requirement, the application of statistical software like R is desirable

Desirable Requirements

  • Robust understanding of the mechanism of action of oligonucleotide therapeutics (alternative splicing, steric blocking of protein translation, RNAseH activity, RISC loading, splice switching, immune stimulation) and basic knowledge of oligonucleotide modeling
  • Professional experience in pharmaceutical drug discovery of NM drug candidates

We would like to know more about you. If you are interested, apply now at

Welcome with your application no later than November 30th, 2019

For more information about the position please contact Dr. Christian Tyrchan, Associate Director, at Christian.Tyrchan[-] or

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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