|CCL 20.11.05 Senior Research Scientist position in computational structural biology, AstraZeneca, Cambridge UK|
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Date: Thu Nov 5 07:15:06 2020
Subject: 20.11.05 Senior Research Scientist position in computational structural biology, AstraZeneca, Cambridge UK
Job Title: Computational Structural Biology Senior Research Scientist Location: Cambridge, UK This is an opportunity for a talented scientist with expertise in Computational Biology, to play an influential role in drug discovery projects at AstraZeneca in Cambridge UK. The Computational Structural Biology (CSB) team has expertise in Structural Bioinformatics, Protein Modelling, protein docking, and in silico prediction of physico-chemical properties of biomolecules. You will collaborate with structural biologists, protein scientists, biophysicists, chemists and biologists across all of AZs therapy areas. You will be part of a team that applies and develops computational methods and platforms to analyse and interpret protein and nucleic acids structures and interactions, with a particular focus on antibody drug discovery. You will contribute to evolve the CSB team to support AZs growing capabilities in RNA therapeutics and to advance computational biology capabilities to positively impact drug discovery projects. Who You Are You will have a PhD in Computational Biology, Structural Biology, Computational Sciences, Biochemistry, or a related discipline and strong practical and theoretical expertise in protein structure and Bioinformatics. You will be skilled in computer programming and have some knowledge of machine learning algorithms. You will have strong personal drive, result focus and a passion to push the boundaries of your science to achieve outstanding results. You have excellent interpersonal and oral and written communication skills. You will have demonstrated ability to work collaboratively in a multidisciplinary team environment. What You Will Do Analyse and interpret protein structure using computational modelling tools; homology modelling and protein-protein docking. Analyse and interpret antibody-antigen interactions, use computational tools to predict physico-chemical properties and predict mutations that enhance affinity and developability of antibodies. Apply molecular dynamics simulations to understand protein dynamics and motions. Generate scripts and workflows to enable automated protein-protein interaction analysis. Contribute to establish computational approaches to nucleic acids, in particular anti-sense oligonucleotides, siRNA and RNA as target. Apply artificial intelligence and machine learning to biologics drug discovery. Be part of and contribute to multidisciplinary drug discovery project teams. Closing Date: 22nd November 2020
Please apply online by clicking on the link https://careers.astrazeneca.com/job/cambridge/computational-structural-biology-senior-research-scientist/7684/17443821NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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