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Date: Mon Nov 23 14:13:26 2020
Subject: 20.11.23 Postdoctoral position in Computational Drug Design
This position is a joint appointment with a nonprofit, mission-focused
research institute, The Baruch S. Blumberg Institute (BSBI), and an 
emerging computational chemistry company, Conifer Point Pharmaceuticals(Conifer).

About US
The Baruch S. Blumberg Institute is an independent, nonprofit research
institute established in 2003 by the Hepatitis B Foundation to conduct
discovery research and nurture translational biotechnology around 
common research themes such as chronic hepatitis, liver disease, and 
liver cancer in an environment conducive to interaction, collaboration 
and focus. It was renamed in 2013 to honor Baruch S. Blumberg, who won 
the Nobel Prize for his discovery of the hepatitis B virus and 
co-founded the Hepatitis B Foundation. 

The mission of Conifer is to be the premier provider of web-based, 
drug design tools so that researchers can access rigorous molecular 
modeling in user friendly format. To do this, the team at Conifer 
Point has made several key scientific breakthroughs in recent years 
in the field of fragment-based drug design that promise to have a 
transformative impact on the discovery of drugs. To make these 
innovations broadly available, we have developed a prototype 
Cloud-hosted Web application for chemical modeling and drug discovery 
including fragment-based design software that is unavailable in any 
other commercial software package. Other industry standard 
methodologies (energy minimization, docking) are also included. A 
computational platform arising from our efforts will be a first-in-class 
molecular design application that is delivered via a browser with fragment 
searches being run in the Cloud (Amazon Web Services). 

BSBI and Conifer are located in a 112,000 ft2 facility known as the 
Pennsylvania Biotechnology Center (PA Biotech Center) in Doylestown, 
PA. The Center is a nonprofit business incubator, funded in part by a 
grant from the Commonwealth of Pennsylvania, whose mission is to 
nurture entrepreneurship and biotechnology in the region. It is home 
to nearly 40 research and biotechnology companies and two non-profits, 
the Blumberg Institute and the Hepatitis B Foundation.  The facility 
provides a shared infrastructure and a collaborative intellectual 
community allowing for synergistic operations of the companies.

The Modeling and Informatics group is seeking a creative, self-motivated 
computational chemist with exceptional interpersonal and problem-solving 
skills to join our scientific team in Doylestown, PA.

The successful candidate will be responsible for the design and 
optimization of novel drug candidates using advanced computational 
techniques, including ligand- and structure-based methods. The 
applicant will apply computation to develop understanding of drug 
resistance and mutation. In addition to participating in the support 
of medicinal chemistry programs, the applicant will be expected to 
continue research in new areas of molecular modeling relevant to the 
drug discovery and development process.


Ph.D. (or expected in next 3 months) in chemistry, biochemistry, 
biophysics or chemical biology with a computational emphasis

Fluency in English and experience in writing scientific papers
Evidence of creative application of computational approaches to problems of pharmaceutical interest
Evidence of integration of chemical biology, target or SAR knowledge into computational design
Track record of publications, posters, and speaking engagements
Experience in modern molecular modeling techniques (docking, molecular simulation, homology modeling, pharmacophore modeling, quantum mechanics, 
QSAR, ligand- and structure-based design) 
Experience with The Schrodinger Drug Discovery Suite, PyMOL
Experience in scientific programming (C++, Javascript, Perl, Python)

Stipend levels follow NIH guidelines.
To apply please email a cover letter describing scientific background and detailed interest in this 
appointment and a CV with a complete list of publications to
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