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Date: Sat Feb 27 15:55:33 2021
Subject: 21.02.27 Applications Scientist - SilcsBio, LLC
At SilcsBio we are passionate about accelerating the pace of drug 
discovery. We are scientists, chemists, programmers, and innovators 
developing and utilizing next generation computer-aided drug design 
for end-to-end solutions in small molecule and biologics development. 
We are seeking a Senior Applications Scientist to manage customer 
service projects as well as support technical software sales. We enable
drug discovery scientists to discover new drug candidates, optimize lead
compound candidates, and facilitate the formulation of protein-based
drugs using a patented physics- and structure-based approach.

-Work as part of a dynamic, inclusive, and eager team who will support 
your professional development, rise to challenges with you, and grow 
-Use our in-house software and third-party commercial modeling software
as well as various open-source software packages to carry out tasks in
a timely fashion
-Interface with customers for technical support and sales
-Perform molecular modeling, including:
     -Molecular dynamics simulations and analysis of receptor/ligand 
     -SILCS simulations and FragMap generation using our GCMC/MD 
     -Pharmacophore and SILCS-based database screening
     -Allosteric binding site identification and characterization
     -Fragment-based drug design and development
     -RMSD and chemical fingerprint cluster analysis
     -SILCS Lead compound optimization 
     -SILCS Biologics protein-based drug formulation
     -Calculation of ligand physiochemical properties for bioavailability 
-Benchmark performance of various computational binding affinity methods
-Contribute to the maintenance, implementation, and development of the 
 SILCS code base

-Ph.D. in Chemistry, Biology, Pharmaceutical disciplines, or related fields
-Robust understanding of molecular modeling in the areas of computational
 chemistry, biology, and biophysics
-Strong background in predictive science including using modeling tools 
 for structure based-drug design, macromolecule design, and antibody modeling
-Ability to work and communicate with customers regularly
-Expertise in Bash and Python scripting
-Experience with scientific software maintenance and development, with 
 expertise in C/C++ desireable
-Familiarity with high-performance computing (HPC) environments

Our offices are located at the center of the entrepreneurial renaissance  
of Baltimore, giving you the opportunity to interact with some of the 
nations most exciting technology companies.
Please send your resume and cover letter to Alex.Meltzer||
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