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Up Directory CCL 21.07.01 Molecular Modelling Mage, Espoo/Turku, Finland
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To: jobs at ccl.net
Date: Thu Jul 1 08:57:15 2021
Subject: 21.07.01 Molecular Modelling Mage, Espoo/Turku, Finland
Orion Corporation operates in more than 20 countries, where we Orionees,
3200 in total, work in all kinds of positions.
Among us there are Research Scientists, Laboratory Technicians,
Engineers and IT Specialists as well as people working in Production,
just to mention some examples. We offer diverse and responsible jobs to
our personnel in a truly multi-disciplinary work environment.
We encourage people to develop their competences and offer opportunities
to affect the job description and creating their own career path at
Orion. We are searching for top talents who are ready to share our
passion for the work that we do. 

Orion is seeking a Molecular Modelling Mage
(an experienced Senior Scientist) to further develop  our capabilities
and push the boundaries of theoretical drug discovery research carried
out in Computational Medicine Design (CMD) unit.


Description of position


The Molecular Modelling Mage will work in the drug discovery projects
linking and interfacing with biology and chemistry with both ab initio
and data-driven perspectives. For this, it is critical to constantly
rediscover the best suitable strategy for each project and define how to
increase the target understanding and how to navigate the path of
multiparameter optimization in modality design. For example, approaches
can be both ligand- and structure-based virtual screening and design,
protein modelling, physics-based simulations, structure-activity data
analysis, machine learning and utilization of variety of in-house and
public data sources. The Molecular Modelling Mage will collaborate
closely with a broad range of scientists including other modellers in
the CMD unit, medicinal chemists, pharmacologists and biologists.


The position is full-time and you will be based in Espoo or Turku, Finland.


Description of unit


Orion is a globally operating Finnish company listed on the Helsinki
Stock Exchange. Orion develops, manufactures and markets human and
veterinary pharmaceuticals, active pharmaceutical ingredients and
diagnostic tests for global markets. Orion's pharmaceutical innovations
are created within its R&D organization, including e.g. non-clinical
research, clinical development, formulation development and medical
affairs. The organization employs top professionals in the field of drug
molecule development and optimization.


Medicine Design contributes to the drug discovery process of Orion R&D
from target validation all the way to the candidate nomination. We are
responsible for translating new drug targets to therapeutical modalities
together with other line functions. Our scientists in biology, chemistry
and computer-aided medicine design are key players in the multiple
research programs driven by Orion's therapy areas of
Neurological Disorders and Oncology. We also support our colleagues
around R&D with our core competences.


Requirements 


To be a successful Molecular Modelling Mage, you should have the
following educational and professional work experiences:



Ph.D. from a suitable field, e.g. computational chemistry,
bioorganic chemistry, biophysics, computer science or biochemistry

Concrete post-doctoral or industrial experience (above five years)

Broad experience in computational drug design,
mastery of state-of-the-art ligand- and structure-based methods
and their applications for medicine design

Solid understanding of fields relevant in the discovery process
(e.g. medicinal chemistry, pharmacology, biochemistry,
cell biology, structural biology, biophysics)


In addition, in depth experience in at least one of the
following aspects:



Application of large-scale modern data science, machine learning
and cheminformatics for drug discovery

Large-scale molecular dynamics simulations
(e.g., relative and absolute free energy methods) for protein-ligand
complexes

Track record of progressing modalities from hit identification through
lead to clinical candidate


Experience with commercial molecular modelling software platforms,
data pipelining tools (e.g. Knime) and programming/scripting/data
analysis/data visualization (e.g. Python) is desirable.


We expect from all scientists the ability to work both independently and
in multidisciplinary teams consisting of in-house scientists and
external collaborators. A demonstrated record of research productivity
and excellent oral and written communication skills in English are
expected.


We offer


We offer you great, highly professional & experienced colleagues and the
opportunity to show your talent and challenge yourself with interesting
tasks in a modern multidisciplinary environment. Computational methods
play a key role in Orion drug discovery so this is an opportunity to
contribute to helping patients in need. Generous health and welfare
benefits are available, as well as support for international relocation. 


Additional information


Is this the position you have been waiting for?
Please send your cover letter and CV by 8th August 2021 and let us know
what inspires you! Our application period is extended due to holida
period in Finland.


For additional information on the position,
please contact Heikki Ksnnen,
Head of Computational Medicine Design, +358104265279,
during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).


Approved medical examination which also includes drug testing is
required prior to the employment. We will also carry out a security
clearance prior to the employment for the selected person.
Please apply directly via our website:
https://www.orion.fi/en/careers/open-vacancies/
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