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Date: Tue Sep 7 09:57:56 2021
Subject: 21.09.07 Sr. Scientist, Computational Drug Discovery; EMD Serono; Billerica MA
Sr. Scientist, Computational Drug Discovery
A career with EMD Serono is an ongoing journey of discovery: our 58,000
people are shaping how the world lives, works and plays through next
generation advancements in Healthcare, Life Science and Electronics.
For more than 350 years and across the world we have passionately 
pursued our curiosity to find novel and vibrant ways of enhancing
the lives of others. EMD Serono is a business of Merck KGaA, Darmstadt,
United As One for Patients, our purpose in Healthcare is to help create,
improve and prolong lives. We develop medicines, intelligent devices
and innovative technologies in therapeutic areas such as Oncology, 
Neurology and Fertility. Our teams work together across 6 continents
with passion and relentless curiosity in order to help patients at 
every stage of life. Joining our Healthcare team is becoming part of 
a diverse, inclusive and flexible working culture, presenting great
opportunities for personal development and career advancement across 
the globe.
Your role: 
EMD Serono in Billerica, MA is seeking a computational molecular modeler 
to support drug discovery projects in our innovative and dynamic 
preclinical portfolio. The Sr. Scientist will join a global team of highly 
motivated, cross-disciplinary scientists and use expertise in molecular 
interaction modeling to design our large molecule (beyond rule of 5) 
drug candidates. The candidate will support biologics and protein 
degradation discovery and new modalities, working closely with wet-lab 
biologists and chemists within Discovery & Development Technologies.

- Design and optimize novel biologics (NBEs) and protein degrader 
(PROTACs) candidates using computational modeling techniques
- Model protein-protein interactions using advanced computational methods
- Leverage protein sequence and structural information to predict and 
optimize biophysical properties of biologics
- Propose degraders (bifunctional and/or glues) by optimizing binding 
to therapeutic target and ligases and designing linkers with improved 
physicochemical and ADME properties
- Work closely with experimental scientists to develop novel therapeutic 
drug candidates

Who you are:
Minimum Qualifications: 
- PhD in Chemistry, Biochemistry, Biophysics, or related Scientific 
discipline with a computational emphasis
Preferred Qualifications:
- 2+ years of drug discovery experience in academia or pharmaceutical/
biotech industry
- Evidence of creative application of computational approaches to 
problems of pharmaceutical interest
- Track record of publications and presentations
- Experience in modern small molecule modeling techniques (docking, molecular 
simulations, QSAR/machine learning, ligand- and structure-based design)
- Experience analyzing protein sequences and structural information with 
an emphasis on protein design (protein-protein docking, protein homology 
modeling and simulation, loop and linker exploration, residue scanning, 
protein stability)
- Experience with modern software packages (Schrodinger, CCG, Rosetta)
- Experience in scientific programming and/or scripting (Python, 
Pipeline Pilot, R)
- Experience in data mining and quantitative analysis of high-volume 
biological data (Spotfire)
- Experience in machine learning and descriptive statistics
- Familiar with antibody, nanobody or large molecules screening and 
production technologies
- Familiar with laboratory techniques in molecular biology, biophysical 
and cellular assays and protein expression and purification 
- Excellent communication and collaboration skills
- Exceptional interpersonal and problem-solving skills
- Ability to work well in multidisciplinary teams
- Capacity to prioritize and work independently, complete tasks and 
advance projects, with minimal supervision

What we offer: With us, there are always opportunities to break new 
ground. We empower you to fulfil your ambitions, and our diverse 
businesses offer various career moves to seek new horizons. We trust 
you with responsibility early on and support you to draw your own 
career map that is responsive to your aspirations and priorities in 
life. Join us and bring your curiosity to life!
Curious? Apply and find more information at
The Company is an Equal Employment Opportunity employer. No employee 
or applicant for employment will be discriminated against on the basis 
of race, color, religion, age, sex, sexual orientation, national 
origin, ancestry, disability, military or veteran status, genetic 
information, gender identity, transgender status, marital status, 
or any other classification protected by applicable federal, state, 
or local law. This policy of Equal Employment Opportunity applies to 
all policies and programs relating to recruitment and hiring, 
promotion, compensation, benefits, discipline, termination, and 
all other terms and conditions of employment. Any applicant or 
employee who believes they have been discriminated against by the 
Company or anyone acting on behalf of the Company must report any 
concerns to their Human Resources Business Partner, Legal, or 
Compliance immediately. The Company will not retaliate against any 
individual because they made a good faith report of discrimination.
Apply here:
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