POSITION:
Synergize Virtual Screening and DNA-Encoded Library Technology for Next Generation Ligand Discovery

HOW MIGHT YOU DEFY IMAGINATION?
You have worked hard to earn your degree and you are now ready to take the next step in your career.
How will you leverage your skills, experience, and passion to work toward your goals? 
At Amgen, our shared mission to serve patients drives all that we do. 
For more than four decades, Amgen has pioneered biotechnology breakthroughs
to bring state-of-the-art medicines from laboratory to patients, reaching over 10 million patients worldwide. 
Come to do your best work alongside other innovative and driven professionals in this meaningful role.

DESCRIPTION
Lets do this. Lets make an impact. This is a unique opportunity to join Amgen Research Copenhagen (ARC) site 
as a Postdoctoral fellow. Using our DNA-Encoded Library (DEL) technology, ARC contributes 
significantly to Amgen's many small-molecule drug discovery projects from hit discovery, 
all the way, to drug candidate selection. In this role, you will be developing and applying 
Virtual Screening methodologies to sharpen the power of DEL screening and associated technologies. 
You will be joining a thriving and scientifically diverse ecosystem, working with 
the world leaders in DEL technology and in close collaboration with experts in medicinal and parallel chemistry
as well as biochemistry, biophysics and biology to tackle challenging Drug Discovery programs. 
You will also have the opportunity to write manuscripts, publish in leading journals, and present data in internal 
and external settings including oral and poster presentations at scientific conferences. 
You will be enrolled in the Amgen postdoc program and be part of the Amgen Research postdoc community 
interacting with fellow postdocs across our research organization.

The postdoctoral fellow will:
- Develop Virtual Screening methods enabling two-way synergy with the DEL screening technology
- Apply DEL screening data insights to enhance virtual small molecule ligand discovery for specific targets
- Explore new paradigms of fragment combination screening within synthetically feasible chemical space
- Investigate the current capabilities of ligand-binding determination and define new standards 
   and state-of-the-art workflows within the field

The postdoctoral fellow will report to Scientific Director, and leader 
of the ARC Research Informatics group, Mads Noerregaard-Madsen (also co-mentor)
and mentored by Research Scientist Loris Moretti, heading the Structural-Based Drug Discovery effort. 
For further information contact: HR Manager Helena Pechter (hpechter~!~amgen.com)

WHAT WE EXPECT OF YOU
We are all different, yet we all use our unique contributions to serve patients. 
The Scientist professional we seek is an innovative leader with these qualifications.

Basic qualifications:
- PhD in a computational chemistry, biophysics, or other related fields
or
- PhD in chemistry combined with at least 3 years postdoc level experience in relevant computation science fields

Preferred qualifications:
- Solid understanding of structure, properties, and interactions of molecules
- Experience with structural biology and molecular modeling, with methods such as docking, 
   and structure- and ligand-based screening
- Knowledge about Molecular Dynamics and Quantum Mechanics applications relevant to drug discovery
- Knowledge of advanced machine learning methods and their applications to computational chemistry/modelling
- Proficiency in Python or other programming/scripting languages
- Experience working in Linux-shell based environment and high-performance computing environments
- Good communicator, able to write and speak about technical concepts to various kind of audiences
- Proficiency in written and spoken English
- Able to work independently, driving ideas forward from initiation to closure

SOME OF THE REWARDS OF WORKING HERE
As we work to develop treatments that take care of others, 
we also work to care for our teammates professional and personal growth and well-being.
- Full support and career-development resources to expand your skills, enhance your expertise, 
   and maximize your potential along your career journey
- A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
- Generous Total Rewards Plan comprising health, finance, work/life balance and other benefits

JOIN US
If you are seeking a career where you can truly make a difference in the lives of others, 
a career where you can work at the absolute forefront of biotechnology with the top minds in the field, 
you will find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. 
Our medicines have helped millions of patients in the fight against cancer, 
kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, 
Amgen fosters an inclusive environment of diverse, ethical, committed 
and highly accomplished people who respect each other but compete intensely to win. 
Together, we live the Amgen values as we continue advancing science to serve patients.

Please note that the position is at our Copenhagen research site and therefore it is required to have or be eligible 
to obtain a permit to live and work in Denmark. All applications and contacts are confidential. 
Candidates should apply as soon as possible since the selection will start shortly.

Please apply for the position at the link below:
https://careers.amgen.com/job/17727841/postdoctoral-fellow-virtual-screening-for-dna-encoded-library-technology/