The research team led by Dr. Stepan Timr (http://www.stepantimr.com) at J. Heyrovsky Institute of
Physical Chemistry in Prague (https://www.jh-inst.cas.cz) offers fully funded PhD positions in
computational biophysics and biomolecular modeling.

We are a research group focusing on the computer simulation of the cell interior. Using multi-scale
molecular models, we aim to elucidate physical and chemical mechanisms governing the organization of
metabolic pathways in living cells. Our research team, supported by the Lumina Quaeruntur Award
as well as by a grant from the Czech Science Foundation, is integrated into the interdisciplinary
Department of Computational Chemistry, connecting the physical chemistry and biophysics of proteins
and membranes with theoretical enzymology and spectroscopy.

The PhD students will use a broad range of computational approaches, ranging from atomistic MD,
coupled with enhanced-sampling techniques and machine learning tools, to coarse-grained and
ultra-coarse-grained simulations. We offer the following three topics of the PhD work:

PhD project 1. Effect of intracellular environment on enzyme function
PhD project 2. Computational modeling of dynamic enzyme assemblies
PhD project 3. Mechanisms of allostery and regulation in glycolysis

For more details about the projects, please see http://www.stepantimr.com/openings.

Requirements:
The candidates are expected to hold a MSc (or an equivalent) in physics, chemistry, or related fields
before the start of the position. They should be interested in biomolecules and motivated to learn
new things. Moreover, they should possess good computer skills and be fluent in English.
Experience with molecular simulations and programming would be a plus. The successful candidates
will enroll at Charles University in Prague, the top-ranking university in the Czech Republic.

Application deadline: March 20, 2023

Starting date: Summer 2023 (no later than October 1)

Benefits:
- 25 days paid leave of absence (holidays) per year + 3 days of paid sick-leave in addition
  to the statutory insurance
- Flexible working-time, the possibility of part-time work, work-life balance
- Lunch vouchers
- Subsidy for sports and cultural activities
- Recreation subsidy, recreation subsidy for children
- Children groups offered by the Czech Academy of Sciences (CAS)
- Possibility to use discounts in recreation centers of the CAS
- Sports goods rental, free parking, trade union library
- Language courses
- Attractive location
- Health and social insurance paid mandatory by the institute

How to apply:
If you are interested, please send us your CV together with your motivation letter, transcripts
of all courses and grades, and two contacts as a reference to recruitment[A]jh-inst.cas.cz.
Please indicate in your application which of the three PhD projects listed above you would be
primarily interested in. Please write in the subject line of your email SC2023_04.
If you have any questions, contact stepan.timr[A]jh-inst.cas.cz.