From Don_Gregory&$at$&MSI.COM Sun Jun 12 12:25:25 1994 Received: from schizoid.msi.com for Don_Gregory&$at$&MSI.COM by www.ccl.net (8.6.4/930601.1506) id LAA28175; Sun, 12 Jun 1994 11:50:56 -0400 Received: from msi.com (qmail-gw.msi.com) by schizoid.msi.com (4.1/SMI-4.1) id AA13346; Sun, 12 Jun 94 11:50:27 EDT Message-Id: <9406121550.AA13346 "-at-" schizoid.msi.com> Date: 12 Jun 1994 11:50:37 +0000 From: "Don Gregory" Subject: Polymorph Prediction Semina To: "OSC BBS" Subject: Time:11:34 AM OFFICE MEMO Polymorph Prediction Seminars Date:6/12/94 Seminar Series Announcement! Announcing a free seminar series for Polymorph Prediction. Polymorphism related problems are commonly encountered in: Pharmaceuticals, Agrochemicals, Pigments, Dyes, Specialty chemicals, Explosives, and other formulation technologies. Today, companies are encountering problems related to polymorphism, while others are exploiting the patent extension opportunities offered by polymorphism. Numerous crucial physico-chemical properties may vary dramatically among polymorphs: product stability, shelf life, vapor pressure, melting point, solubility, bioavailability, morphology, compressibility, density, shock sensitivity, detonation velocity and detonation pressure. During this free half-day seminar series, speakers will present, discuss, and demonstrate C2oPolymorph in the Cerius2 environment, an exciting and innovative technique to predict possible polymorphs of fairly rigid molecules from scratch. This novel Computational Instrument promises to be a break-through in a controversial area. In conjunction with other Cerius2 modules from the C2oCrystal Growth Workbench, C2oPolymorph is an extremely powerful tool to solve polymorphism related problems. Coupling MSI's state-of-the-art modeling environment with the computational speed of Hewlett Packard's PA-RISC 7150 micro-processor, Hewlett Packard and MSI offer a complete solution that is fast, affordable, and easy to use. The series 700 model 735 workstation with the 7150 microprocessor running on 125mhz with performance up to 154MIPS, is ideal for compute intensive and demanding graphics applications. To register for any of the following seminars, call Molecular Simulations Inc. at (617) 229-9800, extension 567 in the U.S. In Europe, call +44 223 413302, extension 31. POLYMORPH PREDICTION SEMINAR SERIES IN EUROPE Monday, 4 July London, England Tuesday, 5 July Brussels, Belgium Wednesday, 6 July Frankfurt, Germany Thursday, 7 July Basel, Switzerland ============ POLYMORPH PREDICTION SEMINAR SERIES IN THE U.S. Tuesday, July 12 Research Triangle Park, NC Wednesday, July 13 Valley Forge, PA Thursday, July 14 Saddle Brook, NJ Friday, July 15 Indianapolis, IN ============ THE AGENDA 8:30am Registration and Continental Breakfast 9:00am "The Commercial Impact of Polymorphism" Dr. Frank J.J. Leusen, MSI 9:30am "The Novel Approach to Polymorph Prediction" Dr. Heinrich R. Karfunkel 10:30am Coffee Break 11:00am "Cerius2 for Polymorph Prediction" Drs. Frank J.J. Leusen and Mark R.S. Pinches 11:30am Cerius2 Product Demonstrations Dr. Mark R.S. Pinches 12:15pm "Industrial Applications of C2oPolymorph" Dr. Stephen J. Maginn 1:00pm Close of Seminar THE SPEAKERS DR. HEINRICH R. KARFUNKEL -- Dr. Karfunkel joined Ciba Geigy in Basel, Switzerland, as group leader of central research molecular modeling in 1986 and is now responsible for the transfer of new computational chemistry techniques to Ciba Geigy world-wide. He studied Chemistry, Biochemistry and Mathematics, and received his Ph.D. in Theoretical Chemistry from Tuebingen University, Germany, where he still lectures. Dr. Karfunkel's current research interests include polymorph prediction, QSPR, materials design, and protein folding. Dr. Mark R.S. Pinches -- Dr. Pinches is a member of the materials science development team and has implemented the innovative C2.Polymorph module in the Cerius2 environment. He received his Ph.D. in Chemical Physics from Southampton University, UK, under the direction of Prof. Tildesley. Before joining Molecular Simulations, Dr. Pinches worked at the Parallel Applications Centre of Southampton University. Dr. Frank J.J. Leusen -- Dr. Leusen is Molecular Simulations' Crystal Growth and Particulate Technology Products Manager. He holds a M.Sc. degree in Pharmacy from Leiden University and a Ph.D. in Chemistry from Nijmegen University, The Netherlands, where he applied molecular modeling to study the crystallization behavior of organic salts. Since 1989, Dr. Leusen has acted as an industrial consultant to Ciba Geigy, Switzerland. Dr. Stephen J. Maginn -- Dr. Maginn joined Molecular Simulations in June 1993 as Senior Applications Scientist after working for ICI/Zeneca's Corporate Crystal Chemistry Team for four years, studying solid state problems throughout the companies' product base. He received his Ph.D. in Chemistry from Liverpool University, UK. To register for any of the following seminars, call Molecular Simulations Inc. at (617) 229-9800, extension 567 in the U.S. In Europe, call +44 223 413302, extension 31.