From MASONJS /at\rpr.rpna.com Sat Sep 28 00:09:43 1996 Received: from interlock.rpr.rpna.com for MASONJS /at\rpr.rpna.com by www.ccl.net (8.7.5/950822.1) id XAA18140; Fri, 27 Sep 1996 23:43:57 -0400 (EDT) Received: by interlock.rpr.rpna.com id AA12192 (InterLock SMTP Gateway 3.0 for CHEMISTRY $#at#$ www.ccl.net); Fri, 27 Sep 1996 23:43:58 -0400 Received: by interlock.rpr.rpna.com (Internal Mail Agent-2); Fri, 27 Sep 1996 23:43:58 -0400 Received: by interlock.rpr.rpna.com (Internal Mail Agent-1); Fri, 27 Sep 1996 23:43:58 -0400 Mr-Received: by mta FWVX01; Relayed; Fri, 27 Sep 1996 23:30:47 -0400 Alternate-Recipient: prohibited Disclose-Recipients: prohibited Date: Fri, 27 Sep 1996 23:06:00 -0400 (EDT) From: "Jonathan S. MASON 610-454-3078" Subject: CCL: Diversity:Beilstein + Job opening To: CHEMISTRY |-at-| www.ccl.net Message-Id: <01I9ZPEJEOP2934WWZ # - at - # mr.fwvx03.com> Mime-Version: 1.0 Content-Type: TEXT/PLAIN; CHARSET=US-ASCII Content-Transfer-Encoding: 7BIT Posting-Date: Fri, 27 Sep 1996 23:21:00 -0400 (EDT) Importance: normal Priority: normal X400-Mts-Identifier: [;74033272906991/1812087 "-at-" FWCL01] A1-Type: MAIL Hop-Count: 1 We are planning to do some diversity etc analyses on the Beilstein database of chemical structures (~6 million) [ -> SMILES -> property analyses & -> 3D for 3 & 4 center pharmacophore analyses]. We would apppreciate any practical hints (and of course results) from anyone who has already tried this type of analysis. Jon Mason masonjs ^%at%^ rpr.rpna.com 1 610 454 3078 [3311 fax] Rhone Poulenc Rorer 500 Arcola Road (SW8), Collegeville PA 19426 We also now have an opening in our Computer-Assisted Drug Design team. Please let anyone who may be interested know and ask them to phone/mail/fax me for more details, or send CV [we are looking for a Ph.D with experience in library design and/or genetic algorithm based CADD methods and/or homology modeling and/or structure based library design and analysis to join our enthusiastic team (4) in new lead generation / medicinal chemistry]