From chemistry-request -8 at 8- ccl.net Wed Nov 19 16:39:45 2003 Received: from MMSSERVER.chla.usc.edu (chl179129.usc.edu [128.125.179.129]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAJLdDRW015764 for ; Wed, 19 Nov 2003 16:39:14 -0500 Received: from 10.3.1.165 by MMSSERVER.chla.usc.edu with ESMTP (CHLA SMTP Relay (MMS v5.5.3)); Wed, 19 Nov 2003 13:40:45 -0700 Received: by NTSMTP01 with Internet Mail Service (5.5.2653.19) id ; Wed, 19 Nov 2003 13:38:28 -0800 Message-ID: <73564B8DE398D61180500008C75D7E49033E5DEC /at\NTMAIL03> From: "Pandey, Jaya" To: "'chemistry-.at.-ccl.net'" Subject: Peptidomimetics Date: Wed, 19 Nov 2003 13:38:26 -0800 MIME-Version: 1.0 X-Mailer: Internet Mail Service (5.5.2653.19) X-WSS-ID: 13A53CD7794867-01-01 Content-Type: text/plain Content-Transfer-Encoding: 7bit X-Spam-Status: No, hits=0.0 required=7.0 tests=none version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Dear All, What criterias one should follow to design the peptide analogues of a membrane receptor in order to bring the effect of a toxic ligand down? I designed few but instead of decreasing the effect somehow they are potentiating the effect of the toxin!! If any one has any advice or experience in this please help! Thanks, Jaya