Polymorph Prediction Semina

                        Subject:                               Time:11:34 AM
   OFFICE MEMO          Polymorph Prediction Seminars          Date:6/12/94
 Seminar Series Announcement!
 Announcing a free seminar series for Polymorph Prediction.
 Polymorphism related problems are commonly encountered in:
 Pharmaceuticals,  Agrochemicals,  Pigments,  Dyes,  Specialty chemicals,
 Explosives, and other formulation technologies.
 Today, companies are encountering problems related to polymorphism, while
 others are exploiting the patent extension opportunities offered by
 polymorphism.  Numerous crucial physico-chemical properties may vary
 dramatically among polymorphs:  product stability, shelf life, vapor pressure,
 melting point, solubility, bioavailability, morphology, compressibility,
 density, shock sensitivity, detonation velocity and detonation pressure.
 During this free half-day seminar series, speakers will present, discuss, and
 demonstrate C2oPolymorph in the Cerius2 environment, an exciting and innovative
 technique to predict possible polymorphs of fairly rigid molecules from
 scratch.  This novel Computational Instrument promises to be a break-through in
 a controversial area.  In conjunction with other Cerius2 modules from the
 C2oCrystal Growth Workbench, C2oPolymorph is an extremely powerful tool to
 solve polymorphism related problems.
 Coupling MSI's state-of-the-art modeling environment with the computational
 speed of Hewlett Packard's PA-RISC 7150 micro-processor, Hewlett Packard and
 MSI offer a complete solution that is fast, affordable, and easy to use.  The
 series 700 model 735 workstation with the 7150 microprocessor running on 125mhz
 with performance up to 154MIPS, is ideal for compute intensive and demanding
 graphics applications.
 To register for any of the following seminars, call Molecular Simulations Inc.
 at (617) 229-9800, extension 567 in the U.S.  In Europe, call +44 223 413302,
 extension 31.
 POLYMORPH PREDICTION SEMINAR SERIES IN EUROPE
 Monday, 4 July
 London, England
 Tuesday, 5 July
 Brussels, Belgium
 Wednesday, 6 July
 Frankfurt, Germany
 Thursday, 7 July
 Basel, Switzerland
 ============
 POLYMORPH PREDICTION SEMINAR SERIES IN THE U.S.
 Tuesday, July 12
 Research Triangle Park, NC
 Wednesday, July 13
 Valley Forge, PA
 Thursday, July 14
 Saddle Brook, NJ
 Friday, July 15
 Indianapolis, IN
 ============
 THE AGENDA
 8:30am	     Registration and Continental Breakfast
 9:00am	     "The Commercial Impact of Polymorphism"
 		Dr. Frank J.J. Leusen, MSI
 9:30am      "The Novel Approach to Polymorph Prediction"
 		Dr. Heinrich R. Karfunkel
 10:30am   Coffee Break
 11:00am      "Cerius2 for Polymorph Prediction"
 		Drs. Frank J.J. Leusen
 		and Mark R.S. Pinches
 11:30am      Cerius2 Product Demonstrations
 		Dr. Mark R.S. Pinches
 12:15pm     "Industrial Applications of C2oPolymorph"
 		Dr. Stephen J. Maginn
 1:00pm        Close of  Seminar
 THE SPEAKERS
 DR. HEINRICH R. KARFUNKEL  --   Dr. Karfunkel joined Ciba Geigy in Basel,
 Switzerland, as group leader of central research molecular modeling in 1986 and
 is now responsible for the transfer of new computational chemistry techniques
 to Ciba Geigy world-wide.  He studied Chemistry, Biochemistry and Mathematics,
 and received his Ph.D. in Theoretical Chemistry
 from Tuebingen University, Germany, where he still lectures.  Dr. Karfunkel's
 current research interests include polymorph prediction, QSPR, materials
 design, and protein folding.
 Dr. Mark R.S. Pinches  --   Dr. Pinches is a member of the materials science
 development team and has implemented the innovative C2.Polymorph module in the
 Cerius2 environment.  He received his Ph.D. in Chemical Physics from
 Southampton University, UK, under the direction of Prof. Tildesley.  Before
 joining Molecular Simulations, Dr. Pinches worked at the Parallel Applications
 Centre of Southampton University.
 Dr. Frank J.J. Leusen --   Dr. Leusen is Molecular Simulations' Crystal Growth
 and Particulate Technology Products Manager.  He holds a M.Sc. degree in
 Pharmacy from Leiden University and a Ph.D. in Chemistry from Nijmegen
 University, The Netherlands, where he applied molecular modeling to study the
 crystallization behavior of organic salts.  Since 1989, Dr. Leusen has acted as
 an industrial consultant to Ciba Geigy, Switzerland.
 Dr. Stephen J. Maginn  --  Dr. Maginn joined Molecular Simulations in June 1993
 as Senior Applications Scientist after working for ICI/Zeneca's Corporate
 Crystal Chemistry Team for four years, studying solid state problems throughout
 the companies' product base.  He received his Ph.D. in Chemistry from Liverpool
 University, UK.
 To register for any of the following seminars, call Molecular Simulations Inc.
 at (617) 229-9800, extension 567 in the U.S.  In Europe, call +44 223 413302,
 extension 31.