the question about the normal mode analysis

Dear CCLs:
 I want to do a normal mode analysis simulation about a protein.
 1, I think it can not include the solvent (water). Is it correct?
 2, how to add the effect derived from the solvent in the NMA simulation?
 Best regards!
             bxiong -AatT-
 Xiong Bin
 Shanghai Institute of Materia Medica, C.A.S.