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Dear CCLers,
Structure-based drug design,or
rational drug design, has been a promising techniques in the discovery and
development of new drugs.
Of course, there have been a lot of
successful examples, such as drugs on HIV protease, thymidine synthase.Some of
them have successfully
been used in the clinic.
However, as great advancements
have taken place in this field, such as FlexX, Gold, GRID and etc, there
should be more and more
successful examples in the structure-based drug design
field. In my view, though these quite
new softwares have been generally used, there
are few examples to demonstrate
their potential in the real drug design process. I am very
interested in this topic. If you have (or know) some
successful examples or experiences in this field,
could
you kindly enough to share this information with me? The method or softwares
used in
the
studies, such as FlexX, GOLD, DOCK4, GRID, Ludi are wellcome.
I will make a detailed
summary.
Song Yunlong, Ph.D
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Dept of med chem
School of pharmacy
Sec Mil Med Univ
Guohe Road,325
Shanghai, 200433
P. R. China
E-mail:songyunlong' at \`hotmail.com
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