W:glycine template isosters
- From: "Jan, , Pedersen" <me)at(torleif.org>
- Subject: W:glycine template isosters
- Date: Fri, 29 Apr 2005 14:31:58 -0400
A question to all of you.
I am trying to list possible isosters of the aminoacid motif H2N-C(R)-COOH or of
glycine if you wish that formulation. I am not interested in this from a polymer
point of view, I am just trying to list species that would have similar
properties (in a QM sense) as glycine or as the aminoacid backbone.
I am looking at a receptor that binds a single aminoacid, and the main
interactions are with the "backbone" H2N- and -COOH groups. So I am
thinking about which other small functional groups may serve this purpose...
Does any of you have any pointers to reviews on this subject or a list of
possible isosters please join in the discussion.
Thanks -- Jan