CCL: Find a lead from a drug

 Sent to CCL by: "Venable, Richard (NIH/NHLBI) [E]"
 [venabler#%#nhlbi.nih.gov]
 It should also be noted that some lead compounds and others investigated may not
 be public knowledge; drug companies do not have to release information about
 molecules they've made and studied unless they wish to put one of them on the
 market.  Certainly, the FDA gets involved before human tests are conducted, but
 if the drug never goes to market, it's chemical structure and biological action
 do not become public knowledge.  That information is regarded as confidential
 trade secrets, owned by the company that developed it.
 --
 Rick Venable      5635FL/T906
 Membrane Biophysics Section
 NIH/NHLBI Lab. of Computational Biology
 Bethesda, MD  20892-9314   U.S.A.
 (301) 496-1905   venabler AT nhlbi*nih*gov
 On 6/29/09 1:36 PM, "Block, John john.block() oregonstate.edu"
 <owner-chemistry=-Ìl.net> wrote:
 Sent to CCL by: "Block, John" [john.block.:.oregonstate.edu]
 One approach is to use Chemical Abstract's SciFinder Scholar.  Enter the
 drug, request the references and filter for articles that describe the
 synthesis or early pharmacological evaluation.  If you are lucky, you
 will find the desired journal article.  Otherwise, it probably is buried
 in the patent literature.
 John Block
 John H. Block                    Phone:  541-737-5779
 College of Pharmacy         Fax:      541-737-3999
 Oregon State University
 Corvallis, OR 97331
 John.Block : oregonstate.edu
 blockj : onid.orst.edu
 -----Original Message-----
 > From: owner-chemistry+john.block==orst.edu : ccl.net
 [mailto:owner-chemistry+john.block==orst.edu : ccl.net] On
 Behalf Of
 Jeremy Besnard j10b84%a%hotmail.com
 Sent: Monday, June 29, 2009 2:15 AM
 To: Block, John H.
 Subject: CCL: Find a lead from a drug
 Sent to CCL by: "Jeremy  Besnard" [j10b84[-]hotmail.com]
 Dear colleagues,
 I have a list of drugs which are on the market and I'd like to find the
 lead compound which was used as starting point for the lead optimization
 process.
 But the artciles related a story of a drug are not easy to find. An easy
 one is The Discovery of Tadalafil:  A Novel and Highly Selective PDE5
 Inhibitor. 2:
 2,3,6,7,12,12a-hexahydropyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione
 Analogues. But by looking for name of drug + discovery in a search
 engine I don't get hits. I also tried with lead, SAR...
 I'd like to know if you have some hints and tips to help find a lead
 with the name of the drug. Also if you know a relatively recent set of
 leads and drugs that could be very useful.
 Thank you.
 Jeremy
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