CCL: Find a lead from a drug
- From: "Venable, Richard (NIH/NHLBI) [E]" <venabler *
- Subject: CCL: Find a lead from a drug
- Date: Mon, 29 Jun 2009 19:50:27 -0400
Sent to CCL by: "Venable, Richard (NIH/NHLBI) [E]"
It should also be noted that some lead compounds and others investigated may not
be public knowledge; drug companies do not have to release information about
molecules they've made and studied unless they wish to put one of them on the
market. Certainly, the FDA gets involved before human tests are conducted, but
if the drug never goes to market, it's chemical structure and biological action
do not become public knowledge. That information is regarded as confidential
trade secrets, owned by the company that developed it.
Rick Venable 5635FL/T906
Membrane Biophysics Section
NIH/NHLBI Lab. of Computational Biology
Bethesda, MD 20892-9314 U.S.A.
(301) 496-1905 venabler AT nhlbi*nih*gov
On 6/29/09 1:36 PM, "Block, John john.block() oregonstate.edu"
Sent to CCL by: "Block, John" [john.block.:.oregonstate.edu]
One approach is to use Chemical Abstract's SciFinder Scholar. Enter the
drug, request the references and filter for articles that describe the
synthesis or early pharmacological evaluation. If you are lucky, you
will find the desired journal article. Otherwise, it probably is buried
in the patent literature.
John H. Block Phone: 541-737-5779
College of Pharmacy Fax: 541-737-3999
Oregon State University
Corvallis, OR 97331
John.Block : oregonstate.edu
blockj : onid.orst.edu
> From: owner-chemistry+john.block==orst.edu : ccl.net
[mailto:owner-chemistry+john.block==orst.edu : ccl.net] On
Jeremy Besnard j10b84%a%hotmail.com
Sent: Monday, June 29, 2009 2:15 AM
To: Block, John H.
Subject: CCL: Find a lead from a drug
Sent to CCL by: "Jeremy Besnard" [j10b84[-]hotmail.com]
I have a list of drugs which are on the market and I'd like to find the
lead compound which was used as starting point for the lead optimization
But the artciles related a story of a drug are not easy to find. An easy
one is The Discovery of Tadalafil: A Novel and Highly Selective PDE5
Analogues. But by looking for name of drug + discovery in a search
engine I don't get hits. I also tried with lead, SAR...
I'd like to know if you have some hints and tips to help find a lead
with the name of the drug. Also if you know a relatively recent set of
leads and drugs that could be very useful.
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