[QSAR] Antwort: Structural alerts for endocrine disruptors

Tue Sep 11 11:49:18 EDT 2007

Dear Monika,

This is not my topic, but enclosed a paper related to your topic:

(See attached file: ToxinVitro-2001.pdf)

There are many papers published, as I recognized just bei Scifinder search,
but mostly are not available as fulltext (mostlyt abstracts, like below)...

______________________________
Polychlorinated Biphenyls, Polychloronated Dibenzo-p-dioxins, and
Polychlorinated Dibenzofurans as Endocrine Disrupters—What We Have Learned
from Yusho Disease*1

Yasunobu Aoki
National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba,
305-8506, Japan
Received 21 June 2000.  Available online 5 March 2002.
Abstract

Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and
polychlorinated dibenzofurans (PCDFs) are persistent environmental
pollutants. In some areas wildlife reproduction has been affected by these
compounds, which are recognized as endocrine disrupters. In 1968 in
northern Kyushu in Japan about 2000 people were poisoned by PCBs and PCDFs
(pyrolysis products of PCBs) which contaminated rice oil. Their condition
was named “Yusho” disease. A similar poisoning by PCBs in Taiwan was named
“Yu-Cheng” disease. The major symptoms of Yusho disease were dermal and
ocular lesions, but some of the symptoms, such as irregular menstrual
cycles and altered immune responses, were notable with respect to the
endocrine disrupting activities of PCBs and related compounds. Several
important observations relevant to the mechanisms of Yusho have been made
from animal studies. For example, a coplanar PCB congener was shown to
cause atrophy of the thymus and PCB administration was thought to alter
androgen metabolism. The most tragic aspect of Yusho and Yu-Cheng diseases
was the exposure of children to PCBs. In the case of Yu-Cheng, children
exposed to PCBs in utero and lactationally were reported to have poor
cognitive development. Intellectual impairment was also observed in
children born to women who had eaten fish contaminated with PCBs in the
United States. From animal studies, alterations in thyroid hormone status,
modulation of protein kinase C, and changes in dopamine levels, etc. were
proposed as the possible mechanisms for the adverse effects of PCBs on
brain development. Whereas coplanar PCB and related congeners, e.g.,
2,3,7,8-tetrachlorodibenzo-p-dioxin, induce gene expression via a
ligand-dependent transactivating factor, the arylhydrocarbon receptor,
alternative pathways for gene expression, e.g., c-Src and cross talk with
the MAP kinase pathway, are also reviewed with respect to understanding the
toxic mechanisms of these compounds. Finally, the “precautionary principle”
is discussed for prevention of the health hazards caused by exposure to
endocrine disrupters.

Author Keywords: polychlorinated biphenyl;
2,3,7,8-tetrachlorodibenzo-p-dioxin; Yusho; endocrine disrupter
___________________________________
List of abstracts:
(See attached file: Endorine-disrupting.rtf)

I hope, it could be of help...

Best regards,
Soheila

Soheila Anzali Ph.D.
Head of Molecular Modeling Laboratory
PLS R&D New Technology Evaluation

Location: A32/311
Phone: +49(0)6151 72 4863
Fax:     +49(0)6151 72 914863
Email:   soheila.anzali at merck.de

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Vorsitzender des Aufsichtsrats: Wilhelm Simson

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Dear colleagues,

currently, I am about to compile a review for the German Environmental
Agency (UBA) about structural features that are suitable to help identify
candidate chemicals that may have endocrine disrupting activities.
To cover established as well as most recent research, I would appreciate
very much if you could provide me with information (reprints, reports,
etc.) about your work in this field. Any indications about other relevant
work are also very welcome.

Thank you very much in advance!

Yours sincerely,

Monika Nendza
________________________
Dr. Monika Nendza
Analytisches Laboratorium
Bahnhofstr. 1
24816 Luhnstedt
Germany
T +49 4875 388
F +49 4875 585
E AL-Luhnstedt at t-online.de

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