QSAR - Life Sciences News Update

From: Bio.com / Bio Online <newsletter^_^bio.com>
Date: Fri, 30 Aug 2002 01:01:00 -0700 (PDT)

Bio.com Life Sciences News Update
August 30, 2002

Produced by Bio Online(r)
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com

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CONTENTS:
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1. Science News: "Plant Compound Kills Brain Tumor Cells"
2. InFocus: "RNA: Tool and Target for Drug Discovery"
3. Featured Event: BioITWorld Conference & Expo
4. Career Center: Biotech Job Fair - September 18th, 2002
5. Jobs of the Week: "Group Leader" and others
6. Market Research: "Biosensors and Bioelectronics"
7. Featured Software: "OLIGO 6"

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Newsletter Sponsored by: WORLD GENOMICS SYMPOSIUM
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Join over 2,000 life science colleagues at World Genomics Symposium
and Exposition, September 18-20, 2002 at the new Atlantic City
Convention Center. Register at http://www.world-genomics.com for FREE
Expo and Poster Presentation admittance when you enter priority code BIO2
before September 7. The same Priority Code gets you $50 off Conference
Admittance in a 60+ session program!

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1. SCIENCE NEWS
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-Plant Compound Kills Brain Tumor Cells
http://www.bio.com/jump.jhtml?id=500026
A chemical isolated from a weed that grows in mountain meadows in the
western United States kills the cells of an aggressive brain cancer that
affects some children. The compound, cyclopamine, blocks a signaling
pathway that appears to be important for the survival of medulloblastoma,
a form of cancer for which there is no effective treatment.

-New Method for Detecting Infectious Diseases
http://www.bio.com/jump.jhtml?id=500027
A research team from Northwestern's Institute for Nanotechnology has
invented a technique for creating thousands of DNA detection probes
made of gold nanoparticles with individual molecules attached. Much like
human fingerprints, these molecules act as unique signals for the presence
of different biological agents. The new detection method, for instance,
can easily distinguish smallpox's distinct "fingerprint" from that of HIV.

-Exploring Caffeine Signaling in Brain Function
http://www.bio.com/jump.jhtml?id=500028
Every morning millions of Americans reach for the world's most popular
drug to help them start their day. "That drug is caffeine," said Dr.
James Bibb, assistant professor of psychiatry at UT Southwestern Medical
Center at Dallas. Bibb is one of the authors of a new report explaining
how caffeine exerts its stimulatory effect by altering the biochemistry
of the brain. The findings appear in an August issue of Nature.

-Nanotubes Could Be Powered by Light Beam
http://www.bio.com/jump.jhtml?id=500029
Medical researchers would like to use nano-scale tubes to push very tiny
amounts of drugs dissolved in water to exactly where they are needed in
the human body. The roadblock to putting this theory into practical use
has been the challenge of building pumps small enough to do the job. The
solution - discovered by researchers at Arizona State University - is to
create a system that does not rely on mechanical parts.

-Signaling Protein Linked to Childhood Brain Cancer
http://www.bio.com/jump.jhtml?id=500030
The most common brain cancer in children may have an Achilles' heel -
the signal from a protein called Hedgehog - according to a report in
the Aug. 30 issue of Science. Scientists have discovered that blocking
the growth signals from Hedgehog in laboratory experiments stops
medulloblastoma tumors in mice and kills medulloblastoma cells taken
from human patients.

-Molecular Mechanism Underlying Anthrax Infection
http://www.bio.com/jump.jhtml?id=500031
The mechanism by which inhaled anthrax disarms and evades the immune
system, enabling the potentially lethal bacteria to rapidly spread
throughout the body, has been described by researchers at the University
of California, San Diego (UCSD) School of Medicine.

-FEATURE: Life's Jokers
http://www.bio.com/jump.jhtml?id=500032
The great majority of the now classical twenty amino acids have been on
the scene for more than a century. Threonine was the last to be discovered
in 1936. There was a scoop in 1986 though when it was discovered that the
UGA codon could produce a new amino acid altogether: selenocysteine. And
why is it new and not simply a modified cysteine? Because it has its own
tRNA which is like granting it a passport. Similarly, in May 2002, the
existence of a 22nd amino acid was reported: pyrrolysine.

To view Industry news, visit:
http://www.bio.com/jump.jhtml?id=500033

To view Research news, visit:
http://www.bio.com/jump.jhtml?id=300009

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2. INFOCUS WEBCAST
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1) "RNA: Tool and Target for Drug Discovery"
Broadcast Thursday, August 29, 2002

*Click here to listen to the audio recording:
http://www.bio.com/jump.jhtml?id=500037

*Click here to enter a drawing for a giveaway from our sponsors:
http://www.bio.com/jump.jhtml?id=500020

*To view all past InFocus Webcast recordings and transcripts, go to:
http://www.bio.com/jump.jhtml?id=500036

   
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3. FEATURED EVENT: Bio/IT World, Nov. 12-14 San Diego, CA
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BioITWorld Conference & Expo is the most comprehensive event in the life
sciences industry to focus exclusively on the integration and utilization
of information technologies across all life sciences discovery and
development processes. Register online at http://www.bioitworldexpo.com
now to receive a FREE BioITWorld Discovery pass. Use priority code BC22
when registering.

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4. CAREER CENTER
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BIOTECH JOB FAIR....
Presented by Bio.com and the San Francisco Chronicle.

IMAGINE the Biggest names in BIOTECH and you are invited to meet them all!

Bay Area biotech and pharmaceutical companies come to this Job Fair to
seek out the most talented life sciences professionals like you.

Attend the Biotech Job Fair and meet face-to-face with top recruiters
and hiring managers in the industry.

This is an exciting event that you can't afford to miss!

Location: South San Francisco Convention Center
Date: Wednesday, September 18th, 2002
Time: 1:00 pm - 6:00 pm

For more information and to pre-register for the job fair, please go to
http://www.bio.com/jump.jhtml?id=500025

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5. JOBS OF THE WEEK
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Cytokinetics: Group Leader, Genomics
http://www.bio.com/jump.jhtml?id=500010

Targesome: Formulation Scientist/Senior Scientist
http://www.bio.com/jump.jhtml?id=500011

Ceregene: Temporary Research Associate
http://www.bio.com/jump.jhtml?id=500012

Celera Genomics: Scientist, Discovery Analysis
http://www.bio.com/jump.jhtml?id=500013

Protea Biosciences: Research Associate
http://www.bio.com/jump.jhtml?id=500014

Arete Associates: Research Scientist
http://www.bio.com/jump.jhtml?id=500015

Baystate Health System: Genetics Director
http://www.bio.com/jump.jhtml?id=500016

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6. MARKET RESEARCH
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Bio.com offers the most comprehensive collection of market research.

-Biosensors and Bioelectronics
http://www.bio.com/jump.jhtml?id=500017
There are over 150 companies currently working in the biosensor and
bioelectronics arena. The strength of these technologies lies in their
flexibility, but this flexibility can also result in some confusion
when considering their market potential. This study will provide an
analysis of the major players in this space by cataloguing and
characterizing the various technologies, their major applications,
and the industry leaders in each category. This report is particularly
timely, because the cloning of the human genome and recent advances
in miniaturization of electronic circuits has created an urgent need
for these devices.

-Micronews
http://www.bio.com/jump.jhtml?id=500018
Yole has released a new magazine named Micronews that covers the Bio &
Microfluidic Chip and Microelectronic industries that are relevant to the
Life Science community. Micronews provides information on: A selection
of the monthly key data and figures, market and technology trends,
alliances & mergers, latest business news, creation of new startups,
building of new facilities, lays-off and closings, and much more!!

-Pulmonary/Lung Disease Therapeutics: Worldwide Markets and Developments
http://www.bio.com/jump.jhtml?id=500019
In the U.S., lung disease is ranked as the fourth-leading cause of death
(after heart disease, cancer, and stroke) and is responsible for
approximately 1 in 7 deaths. However, while the death rates for heart
disease and cancer are in decline, the death rate for lung disease is
increasing. This report provides analyses of the U.S. and world markets
for drug therapeutics to treat pulmonary/lung diseases and disorders. The
report focuses on pulmonary disease therapies worldwide and includes an
analysis of future developments in the treatment of respective conditions.
Global regional market size projections (in U.S. dollars) and shares are
covered, as well as discussion of market competitors and products.

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7. FEATURED SOFTWARE
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Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

-OLIGO 6
http://www.bio.com/jump.jhtml?id=500021
Oligo software is used for designing and analyzing oligonucleotide
primers and synthetic genes. Based on nearest neighbor thermodynamics,
Oligo's search algorithms find optimal primers for PCR (including
multiplex, consensus or degenerate primers, inverse PCR, and site
directed mutagenesis), sequencing, and hybridization probes. For each
primer or primer pair, Oligo's various analysis windows show a multitude
of useful data. You can save the primers to a primer database for future
reference and multiplex analysis, and fill a synthesis order form that
you can fax or email to an oligo synthesis facility.

-ModelMaker 4
http://www.bio.com/jump.jhtml?id=500022
Whether you are a research scientist, consultant or a teacher, ModelMaker
is your ideal modeling environment. Its no nonsense approach to modeling
and in-depth functionality brings modeling to novices and experts alike.
ModelMaker's extensive range of functions allow you to model just about
any system - continuous and discontinuous functions, stiff systems and
stochastic systems. Rationalize your results using ModelMaker's analysis
methods - optimization, minimization, Monte Carlo and sensitivity analysis.

-Antimicrobial Databases
http://www.bio.com/jump.jhtml?id=500023
Includes over 1,100 antiviral, antibacterial, antifungal, antiprotozoal,
antiseptic and biocidal compounds used as pharmaceuticals, in industrial
uses and as fungicides. All databases include structures, information
from the literature (use, CAS numbers, melting point, boiling point, etc.)
and calculated values from Molecular Modeling Pro.

Click here to browse through our software catalogue:
http://www.bio.com/jump.jhtml?id=500024

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Copyright (c) 2002 Bio Online, Inc. All rights reserved.
Received on 2002-08-30 - 03:47 GMT

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