QSAR - Life Sciences News Update

From: Bio.com / Bio Online <newsletter%x%bio.com>
Date: Wed, 4 Sep 2002 01:37:47 -0700 (PDT)

Bio.com Life Sciences News Update
September 4, 2002

Produced by Bio Online(r)
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com

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CONTENTS:
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1. Science News: "Virus Driven to Extinction with Cancer Drug"
2. InFocus: "RNA: Tool and Target for Drug Discovery"
3. Featured Event: "World Genomics Symposium"
4. Career Center: Biotech Job Fair - September 18th, 2002
5. Jobs of the Week: "Senior Research Associate" and others
6. Market Research: "The Market for Prescription Antiviral Drugs"
7. Featured Software: "SpecManPlus" and more

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Newsletter Sponsored by: Questra Corporation
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study to see device relationship management in action.
http://www.questra.com/webinar

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1. SCIENCE NEWS
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-240-Million Year Old Protein Recreated
http://www.bio.com/jump.jhtml?id=500058
Call it "Triassic Park": with statistics, instead of amber-preserved DNA,
researchers at the Howard Hughes Medical Institute at The Rockefeller
University and Yale University recreated in the test tube a functional
pigment that would have characterized the eyes of archosaurs ("ruling
reptiles") and allowed these direct ancestors to dinosaurs to see in
dim light.

-New High-Throughput Mass Spectrometer
http://www.bio.com/jump.jhtml?id=500059
A faster, more thorough mass spectrometry method for identifying proteins
may significantly advance the technology infrastructure required to
comprehend the role proteins play in cellular function and disease
development. Already, the one-of-a-kind system, developed at the Department
of Energy's Pacific Northwest National Laboratory, is beginning to provide
new insights into how microorganisms gobble carbon out of the atmosphere
and the role proteins play in a virus known to cause blindness.

-Targeting Enzymes that Immortalize Cancer Cells
http://www.bio.com/jump.jhtml?id=500060
Discovery of a clever trick that cancer cells use to make themselves
immortal may lead to a way to stop their unchecked growth, according to
scientists at the University of California, Berkeley. They describe a
significant difference between the way normal and cancerous cells handle
an enzyme called telomerase, which is critical to unrestricted cell
growth. The enzyme maintains the telomeres that cap the ends of each
chromosome, keeping them long enough so that DNA replication and cell
division go without a hitch.

-Protein that Directs Formation of Synapses
http://www.bio.com/jump.jhtml?id=500061
Researchers at UT Southwestern Medical Center at Dallas have identified
one of the key proteins involved in the establishment of the central
nervous system. They found that the protein, SynCAM, plays a major role
in the formation of synapses, which are specialized junctions at which a
neuron communicates with a target nerve cell.

-Virus Driven to Extinction with Cancer Drug
http://www.bio.com/jump.jhtml?id=500063
For decades, scientists have tried to figure out how to stop viruses
from spreading. But because viruses' genetic machinery has the ability
to replicate and mutate so quickly, viruses rapidly become resistant
to individual anti-viral drugs. Now, researchers report that treating a
common virus with a mutation-causing cancer drug caused the virus to
mutate so much that it was no longer able to reproduce and was driven
to extinction.

-Sugars Show Therapeutic Potential
http://www.bio.com/jump.jhtml?id=500064
Targeting sugars that occur naturally in the body could protect the
kidneys or other organs from damage associated with disease or injury,
according to a Johns Hopkins study. The mouse study indicates that
knocking out the normal function of certain enzymes can protect the
kidney from damage and inflammation following blood flow blockage.

-FEATURE: The Case for Activity-Based Proteomics
http://www.bio.com/jump.jhtml?id=500065
Proteomics attempts to elucidate the actual expression and action of the
genome in different cell types and states. One important aspect of this
is where and when the proteins are working in the human body, and how they
are turned on or shut off in certain cell types, times, or conditions like
infection or cancer. A new proteomics technology, which is being developed
and applied by two investigators at The Scripps Research Institute, seeks
to answer an even more profound question - which proteins are active in a
given cell, tissue, or disease state?

To view Industry news, visit:
http://www.bio.com/jump.jhtml?id=500038

To view Research news, visit:
http://www.bio.com/jump.jhtml?id=500039

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2. INFOCUS WEBCAST
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1) "RNA: Tool and Target for Drug Discovery"
Broadcast Thursday, August 29, 2002

*Click here to listen to the audio recording:
http://www.bio.com/jump.jhtml?id=500040

*Click here to enter a drawing for a giveaway from our sponsors:
http://www.bio.com/jump.jhtml?id=500041

*To view all past InFocus Webcast recordings and transcripts, go to:
http://www.bio.com/jump.jhtml?id=500042

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3. FEATURED EVENT: WORLD GENOMICS SYMPOSIUM
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Join over 2,000 life science colleagues at World Genomics Symposium
and Exposition, September 18-20, 2002 at the new Atlantic City
Convention Center. Register at http://www.world-genomics.com for
FREE Expo and Poster Presentation admittance when you enter
priority code BIO2 before September 7. Same Priority Code gets
you $50 off Conference Admittance in a 60+ session program!

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4. CAREER CENTER
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BIOTECH JOB FAIR....
Presented by Bio.com and the San Francisco Chronicle.

IMAGINE the Biggest names in BIOTECH and you are invited to meet them all!

Bay Area biotech and pharmaceutical companies come to this Job Fair to
seek out the most talented life sciences professionals like you.

Attend the Biotech Job Fair and meet face-to-face with top recruiters
and hiring managers in the industry.

This is an exciting event that you can't afford to miss!

Location: South San Francisco Convention Center
Date: Wednesday, September 18th, 2002
Time: 1:00 pm - 6:00 pm

For more information and to pre-register for the job fair, please go to:
http://www.bio.com/jump.jhtml?id=500043

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5. JOBS OF THE WEEK
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Look at what's new in the Bio.com Career Center this week:

1. Ligand Pharmaceuticals: Senior Research Associate
http://www.bio.com/jump.jhtml?id=500054

2. Protea Biosciences: VP of Business Development
http://www.bio.com/jump.jhtml?id=500055

3. Ceregene: Temporary Research Associate
http://www.bio.com/jump.jhtml?id=500056

4. The Burnham Institute: Chemical Genomics Scientist
http://www.bio.com/jump.jhtml?id=500057

Register today and start using our new features:
http://www.bio.com/jump.jhtml?id=500044

Click here to browse all jobs from Bio.com's Career Center:
http://www.bio.com/jump.jhtml?id=500045

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6. MARKET RESEARCH
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Bio.com offers the most comprehensive collection of market research.

-Commercializing on Tumor Antigens: Analytical Perspectives
http://www.bio.com/jump.jhtml?id=500048
A new report from BioSeeker Group is available to provide you with
in-depth coverage, candid information and analysis of the tumor antigen
field. This report presents an up-to-date "de novo" approach and is a
significant tool for strategic planning in tumor antigen commercialization
whether being a CEO, business developer at a biotech enterprise or an
investment analyst at a VC firm. They have identified more than 60 tumor
antigens that are in line for commercialization. The report focuses on
the achievements and pitfalls experienced by companies trying to
commercialize on these techniques and provides the strategic analysis
needed to sharpen your competitive edge. In this report, they present an
extensive overview of business to business collaborations in the
competitive landscape of tumor antigen commercialization.

-Healthcare Venture Capital Report (2Q 02)
http://www.bio.com/jump.jhtml?id=500049
Growthink's Healthcare Venture Capital Report (2Q 02) analyzes and
profiles the 162 healthcare companies that raised venture capital in
the second quarter of 2002 (representing 2 billion USD) and more than
85 investors that funded two or more healthcare ventures. All company
and investor profiles include complete contact information. The report
is organized by 5 key sectors: Biotechnology/Pharmaceutical,
Diagnostic/Patient Care, Healthcare Software & Services, Healthcare
Content & Commerce and Medical Devices.

-The Market for Prescription Antiviral Drugs
http://www.bio.com/jump.jhtml?id=500050
The Global Market for Prescription Antiviral Drugs is designed to provide
the reader with a comprehensive analysis of viruses and the drugs to
treat diseases caused by viruses. Each segment provides an overview of
significant treatments and market size and growth for global markets.
Markets are divided according to drug class. The report is directed to
decision-makers in the various areas of prescription antivirals to
present insight into those areas for current and future development.

Click here to browse through our publications catalogue:
http://www.bio.com/jump.jhtml?id=500046

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7. FEATURED SOFTWARE
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Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

-Hyperchem 7 for Windows Plus Boxed Book Set
http://www.bio.com/jump.jhtml?id=500051
HyperChem is a sophisticated molecular modeling environment that is known
for its quality, flexibility, and ease of use. Uniting 3D visualization
and animation with quantum chemical calculations, molecular mechanics,
and dynamics, HyperChem puts more molecular modeling tools at your
fingertips than any other Windows program. The newest version, HyperChem
Release 7.01, is a full 32-bit application, developed for the Windows 95,
98, NT, ME, 2000 and XP operating systems. HyperChem Release 7.01
incorporates even more powerful computational chemistry tools than ever
before, as well as newly incorporated modules, additional basis sets,
new drawing capabilities and more.

-OLIGO 6
http://www.bio.com/jump.jhtml?id=500052
Oligo software is used for designing and analyzing oligonucleotide
primers and synthetic genes. Based on nearest neighbor thermodynamics,
Oligo's search algorithms find optimal primers for PCR (including
multiplex, consensus or degenerate primers, inverse PCR, and site
directed mutagenesis), sequencing, and hybridization probes. For each
primer or primer pair, Oligo's various analysis windows show a multitude
of useful data. You can save the primers to a primer database for future
reference and multiplex analysis, and fill a synthesis order form that
you can fax or email to an oligo synthesis facility.

-SpecManPlus
http://www.bio.com/jump.jhtml?id=500053
This software provides an interactive graphical analysis tool for
scientists working with a variety of spectroscopic data. It imports a
variety of formats (Bruker, Varian, JEOL, NMRPipe, NUTS, Felix, JCAMP,
Galactic, Triad, NMR-Compass, etc.) of 1D, 2D, 3D and nD processed
spectrum files for concurrent display and analysis in multiple views.
SpecManPlus enables the user to access 1D and 2D NMR data processing
programs from within SpecManPlus. This software extracts chemical
shifts and other spectral parameters by using sophisticated peak
picking procedures including grid-intelligence-based peak picking. It
also provides tools for viewing 2D planes from 3D or nD spectra and
enables tying and concurrent zooming of 2D and 3D spectra.

Click here to browse through our software catalogue:
http://www.bio.com/jump.jhtml?id=500047

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Copyright (c) 2002 Bio Online, Inc. All rights reserved.
Received on 2002-09-04 - 04:23 GMT

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