Bio.com Life Sciences News Update
September 11, 2002
Produced by Bio Online(r)
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com
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CONTENTS:
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1. Science News: "Sex-Pheromone Link to Insect Evolution"
2. InFocus: "RNA: Tool and Target for Drug Discovery"
3. Featured Event: "Chips-to-Hits 2002"
4. Career Center: Biotech Job Fair - September 18th, 2002
5. Jobs of the Week: "Lab Director" and others
6. Market Research: "DNA Sequencing" and other titles
7. Featured Software: "Molecular Analysis Pro" and more
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Newsletter Sponsored by: BioMedical Asia and BioTechnica Asia 2002
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BioMedical Asia and BioTechnica Asia 2002
Asia Pacific's Premier BioScience Conference and Exhibition
28-30 October 2002, Raffles City Convention Centre, Singapore
Conference Open for Registration!
Register ONLINE NOW at BIOMEDTECHASIA.COM . . . and guarantee
your seat at the industry's hottest event or for more information
please contact the organizers at biomedtechasia]_[hfasin.com
http://www.bio.com/jump.jhtml?id=500072
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1. SCIENCE NEWS
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-Sex-Pheromone Link to Insect Evolution
http://www.bio.com/jump.jhtml?id=600011
Cornell University entomologists have unlocked an evolutionary secret to
how insects evolve into new species. The discovery has major implications
for the control of insect populations through disruption of mating,
suggesting that over time current eradication methods could become
ineffective, similar to the way insects develop pesticide resistance.
-Potential Role of CRP In Atherosclerosis
http://www.bio.com/jump.jhtml?id=600012
Another piece of the complex puzzle of how inflammation is involved in
heart attacks and strokes has been discovered by researchers at the
University of California, San Diego (UCSD) School of Medicine. Their
findings demonstrate that C-reactive protein (CRP) binds to oxidized
low density lipoprotein (LDL), implicating the interaction of CRP and
oxidized LDL as a potential trigger for the cascade of events leading
to atherosclerosis.
-Gene Therapy Treats Rare Disorder in Dogs
http://www.bio.com/jump.jhtml?id=600013
For the first time, researchers have successfully used gene therapy to
treat a disease that affects organs throughout the body of a large
animal. The study involved dogs with a rare disorder in which an enzyme
deficiency causes clouding of the corneas, cardiac disease and bone
abnormalities leading to loss of mobility by six months of age.
-Stopping the Nonsense in Molecular Coding
http://www.bio.com/jump.jhtml?id=600014
There's little room for nonsense in medicine. Stopping even just a little
molecular nonsense would open up new vistas for pharmaceutical companies
and could help alleviate many types of disease, say scientists at the
University of Rochester Medical Center who are building their reputation
on understanding how cells deal with "nonsense."
-New DNA Typing Method Could ID Some 9/11 Victims
http://www.bio.com/jump.jhtml?id=600015
A new DNA analysis technique under development at Ohio University may
help authorities identify the remains of victims of the 9/11 terrorist
attacks when conventional tests don't work. The method could offer
forensic scientists a new tool to examine badly degraded remains - such
as those at the World Trade Center disaster site - and could help police
name perpetrators of crimes.
-Role for Sex-Specific Medicines
http://www.bio.com/jump.jhtml?id=600016
Women with narcolepsy, a disorder characterized by excessive and
overwhelming daytime sleepiness, respond differently than men to treatment
with the drug modafinil. This difference may be due to a sex-specific
variation in one gene, according to results of a recent study. This
finding adds to a growing body of evidence suggesting that so-called
geneticpolymorphisms may vary not only by race and ethnicity, but by sex
too.
-FEATURED MOLECULES: Chaperones
http://www.bio.com/jump.jhtml?id=600017
Most protein chains fold spontaneously into their final structure,
driven by the need to shelter their carbon-rich portions from the
surrounding water. But some-large proteins or proteins with several
domains-need some assistance. Chaperones are proteins that guide
proteins along the proper pathways for folding.
To view Industry news, visit:
http://www.bio.com/jump.jhtml?id=500070
To view Research news, visit:
http://www.bio.com/jump.jhtml?id=500071
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2. INFOCUS WEBCAST
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1) "RNA: Tool and Target for Drug Discovery"
Broadcast Thursday, August 29, 2002
*Click here to listen to the audio recording:
http://www.bio.com/jump.jhtml?id=500073
*Click here to enter a drawing for a giveaway from our sponsors:
http://www.bio.com/jump.jhtml?id=500074
*To view all past InFocus Webcast recordings and transcripts, go to:
http://www.bio.com/jump.jhtml?id=500075
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3. FEATURED EVENT: IBC USA Conferences: Chips-to-Hits 2002
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-Chips to Hits(R), IBC Life Sciences' 9th international event, is coming
to Philadelphia from October 27-31, 2002. This event is regarded as the
world's premier microtechnology meeting for Life Sciences and features
more Big Pharma, academic and end-user presentations than ever before!
Highlights: Microarray applications in genomics, proteomics, informatics,
drug discovery and diagnostics.
http://www.bio.com/jump.jhtml?id=500076
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4. CAREER CENTER
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BIOTECH JOB FAIR....
Presented by Bio.com and the San Francisco Chronicle.
IMAGINE the Biggest names in BIOTECH and you are invited to meet them all!
Bay Area biotech and pharmaceutical companies come to this Job Fair to
seek out the most talented life sciences professionals like you.
Attend the Biotech Job Fair and meet face-to-face with top recruiters
and hiring managers in the industry.
This is an exciting event that you can't afford to miss!
Location: South San Francisco Convention Center
Date: Wednesday, September 18th, 2002
Time: 1:00 pm - 6:00 pm
For more information and to pre-register for the job fair, please go to:
http://www.bio.com/jump.jhtml?id=500077
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5. JOBS OF THE WEEK
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Look at what's new in the Bio.com Career Center this week:
1. King Pharmaceuticals: Analytical Development Chemist
http://www.bio.com/jump.jhtml?id=500078
2. Protea Biosciences: Lab Director
http://www.bio.com/jump.jhtml?id=500079
3. Biotech Company (TaxSearch): Audit Manager
http://www.bio.com/jump.jhtml?id=500080
4. Genentech: Bioinformatics Associate/Associate Bioinformatics Scientist
http://www.bio.com/jump.jhtml?id=600001
5. Sangamo BioSciences: Scientist
http://www.bio.com/jump.jhtml?id=600002
6. Sunesis: Research Associate
http://www.bio.com/jump.jhtml?id=600003
7. Guava Technologies: Technical Specialist
http://www.bio.com/jump.jhtml?id=600004
Register today and start using our new features:
http://www.bio.com/jump.jhtml?id=500069
Click here to browse all jobs from Bio.com's Career Center:
http://www.bio.com/jump.jhtml?id=500068
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6. MARKET RESEARCH
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Bio.com offers the most comprehensive collection of market research.
-The Evolving Drug Industry: New Strategies, Product Trends (2002)
http://www.bio.com/jump.jhtml?id=600005
The pharmaceutical industry is an evolving one driven by scientific and
technological advances, new drug discoveries, advances in therapeutic
knowledge and changes in government and regulatory controls. Innovative
new technologies have led pharmaceutical researchers to many new
discoveries, many of which are derived from new knowledge of the cellular
mechanism of disease. This report describes and discusses the evolving
drug industry with an emphasis on product trends and the strategic
actions being taken by the U.S. drug industry to continue its success.
-Male and Female Sexual Dysfunction: Blockbuster Indication for Multiple
Pharmacological Targets
http://www.bio.com/jump.jhtml?id=600006
In March, 1998, Pfizer launched sildenafil (Viagra) for the treatment of
erectile dysfunction. This move had an explosive effect on Pfizer's
financial figures. More generally, this pharmaceutical milestone changed
public awareness of erectile dysfunction and boosted basic research
activity relating to improved understanding and treatment of this
problem. Just over 4 years later LeadDiscovery has produced a state of
the art analysis of sexual dysfunction. Despite the success of sildenafil,
blockbuster opportunities still exist, both for improved treatment of
erectile dysfunction and for the treatment of the largely ignored area
of female sexual dysfunction.
-DNA Sequencing
http://www.bio.com/jump.jhtml?id=600007
DNA sequence information is critical to understanding genetic variations,
which can influence disease and genetic interactions, which can influence
drug efficacy. As such, automated sequencers play a vital role in the
drug discovery process. The use of sequencers in drug discovery has
expanded beyond simply decoding genomes to understanding cellular messages
in the hopes of developing novel drug compounds. Based on a 31-question
survey of more than 230 qualified scientists, DNA Sequencing is the first
of six titles in the series and specifically examines the applications of
automated DNA sequencers and DNA sequencing kits.
Click here to browse through our publications catalogue:
http://www.bio.com/jump.jhtml?id=500067
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7. FEATURED SOFTWARE
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Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:
-Molecular Analysis Pro
http://www.bio.com/jump.jhtml?id=600008
QSAR (quantitative structure activity relationships) and QSPR
(quantitative structure property relationships) study relationships
between useful molecular properties (like ability to control a human
disease) and the underlying chemical and physical properties which may
enhance or limit the desired property. Molecular Analysis Pro has three
main features that aid in the discovery of these relationships: 1.
calculates molecular properties from structure; 2. contains statistical
and graphing tools for analyzing data; and 3. data base storage,
retrieval and manipulation capacity. Molecular Analysis Pro accomplishes
these tasks easily and efficiently, with tools not found elsewhere.
-Amino Acid Databases
http://www.bio.com/jump.jhtml?id=600009
Over 500 natural and synthetic amino acids! All databases include
structures, information from the literature (use, CAS numbers, melting
point, boiling point etc.) and calculated values from Molecular Modeling
Pro. Available in three formats: Molecular Analysis Pro (can be read by
MAP and almost any spreadsheet program - this is an ASCII csv file);
CambridgeSoft's ChemFinder format; MDL SD File.
-TANDY
http://www.bio.com/jump.jhtml?id=600010
Torsion Angle approach to Nucleic acid Distance geometrY
TANDY provides a fast means of generating a family of DNA structures,
consistent with NMR distance constraints. It takes explicit advantage
of the chemical structure and connectivity of the given sequence of
DNA to derive information on the torsion dependence of interatomic
distances. TANDY's fast-minimization algorithm is ideal for interactive
use in conjunction with other complementary algorithms (such as those
used for spectral simulation, energy minimization and molecular dynamics
calculations). Its fast zip-up algorithm is efficient in minimizing
double-stranded DNA structures, and its torsion space algorithm ensures
unbiased sampling of the conformational space. TANDY uses fixed sugar
geometry in each nucleotide during minimization.
Click here to browse through our software catalogue:
http://www.bio.com/jump.jhtml?id=500066
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Copyright (c) 2002 Bio Online, Inc. All rights reserved.
Received on 2002-09-10 - 23:23 GMT
This archive was generated by hypermail 2.2.0 : 2005-11-24 - 10:21 GMT