> My guess
> is that their PR department added some 'facts' of their own,
I agree with Dick, this looks very much like a re-writing by a PR department! I would not be surprised if Bartfai had actually stated that all these approved drugs are represented by 433 *scaffolds* (not *molecules*), but I'm afraid the term of 'scaffold' is hardly understandable to non experts of the field.
If so, that would not be a big surprise: maybe some of you still have in mind this paper by Mark Murcko & al in DDT some years ago showing that the top 1000 drugs were based on only 32 scaffolds.
Well, I guess this PR department would be even more fascinated to realise that all these 10,000 drugs are all based on only 10 to 12 atomic types :-)....
Roger
____________________________
Dr Roger Lahana
Vice President Discovery
Syntem
Received on 2002-11-15 - 03:50 GMT
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