ࡱ> E@ 0:bjbj ,:, , , , , , ,  r9r9r9r9t9 Q;;;;;<<<HHHH1H0L0Q$RRTh>Q, <<<<<>Q, , ;;SQ???<, ;, ;H?<H?\?G@:A,, , kA;; 0* 5r9s=3A BiQ0Q=A.WU%>WUkA@ T 6, , , , WU, kA(<<?<<<<<>Q>Q #? # LogP2004 Symposium Physicochemical and Biological Profiling in Drug Research Provisional programme, Version 7 November 2003 Sunday February 29, 200417h00Opening ceremony Chair 17h00-18h20 Gerd Folkers17h30 -18h20Opening lecture (L1): "Pharmaceutical research: for whom, for what ?"David J. Triggle (State University of New York at Buffalo, USA)18h30 Welcome reception Monday March 1, 2004Experimental ADMET methods (first part, L2 to L4) Chair 09h00-11h30 Heidi Wunderli09h00 -09h40Cell culture absorption models: state of the art (L2)Per Artursson (University of Uppsala, Sweden)09h40 -10h20Coordination of uptake and efflux transporters in drug disposition (L3)Yuichi Sugiyama (University of Tokyo, Japan)10h20-10h50 Coffee break10h50 -11h30Metabonomics in toxicity screening (L4)Jeremy K. Nicholson (Imperial College London, UK) Computational approaches (first part, L5) Chair 11h30-15h10 Raimund Mannhold11h30 -12h10Mining of physicochemical and PK databases (L5) Kiyohiko Sugano (Chugai Pharmaceuticals, Japan)12h10-13h30 Lunch13h30 -15h10Poster session A (authors present) and software demos13h30 -15h10Oral communications (20 min) (OC1 to OC5)15h10-15h40 Coffee breakComputational approaches (second part, L6 & L7) Chair 15h40-17h00 Bernard Testa15h40 -16h20Using computer reasoning about diverse information to predict metabolism and toxicity (L6)Philip N. Judson (Lhasa, UK)16h20 -17h00High throughput automated parallel synthesis in support of early drug discovery: Balancing chemistry development and the desired physicochemical library profile (L7)Carmen M. Baldino (ArQule, Boston, USA) Tuesday March 2, 2004Experimental methods in phys-chem profiling (first part, L8 to L11) Chair 09h00-12h10 Bernard Faller09h00 -09h40Property-based lead optimization (L8)Han van de Waterbeemd (Pfizer, UK)09h40 -10h20Accelerated stability studies (L9)Edward H. Kerns (Wyeth Research, USA)10h20-10h50 Coffee break10h50 -11h30HT technologies in phys-chem profiling (L10)John Comer (Sirius, UK) 11h30 -12h10Lipophilicity profiles of ions and zwitterions (L11)Giulia Caron (University of Turin, Italy)12h10-13h30 LunchComputational approaches (third part, L12 & L13) Chair 13h30-17h00 Pierre-Alain Carrupt13h30 -14h10The BioPrint platform: a profiling database and predictive models for the evaluation of pharmacological and ADMET properties (L12)Frdrique Barbosa (Cerep, France)14h10 -14h50Use of pharmacophore models in predictive ADME (L13)Osman F. Gner (Accelrys, USA)14h50-15h20 Coffee break15h20 -17h00Poster session B (authors present) and software demos15h20 -17h00Oral communications (20 min) (OC6 to OC10) Wednesday March 3, 2004Experimental ADMET methods (second part, L14 to L17) Chair 09h00-11h30 Jennifer Dressman09h00 -09h40Metabolic studies in drug R&D (L14)Bernard Walther (Servier, France)09h40 -10h20HT protein binding studies (L15)Roger E. Fessey (AstraZeneca, UK)10h20-10h50 Coffee break10h50 -11h30The biophysics of membranes (L16)Ole Mouritsen (University of Southern Denmark)Computational approaches (fourth part, L17 to L19) Chair 11h30-14h50 Hugo Kubinyi11h30 -12h10The concept of lipophilicity space (L17)Giulio Vistoli (University of Milan, Italy)12h10-13h30 Lunch13h30 -14h10Molecular fields in ADME screening (L18)Gabriele Cruciani (University of Perugia)14h10 -14h50Predictive physiological models (L19)Thierry Lav (Roche, Switzerland)14h50-15h20 Coffee break15h20 -17h00Poster session C (authors present) and software demos15h20 -17h00Oral communications (20 min) (OC11 to OC15) Chair 15h20-17h00 Stefanie Krmer Thursday March 4, 2004Experimental methods in phys-chem profiling (second part, L20 to L23) Chair 09h00-12h10 Colin Peake09h00 -09h40HT solubility and permeability profiling (L20)Alex Avdeef (pION, USA)09h40 -10h20Phys-chem characterization of the solid state in drug development (L21)Danielle Giron (Novartis, Switzerland)10h20-10h50 Coffee break10h50 -11h30HT-HPLC methods in phys-chem profiling (L22)Franco Lombardo (Pfizer, USA)11h30 -12h10Partitioning/permeation in artificial membranes (L23)Stefanie D. Krmer (ETHZ, Switzerland)12h10-14h00 LunchClosing lectures (L24 to L26) Chair 14h00-16h40 Bernard Testa14h00 -14h40Educational and communication issues related to profiling compounds for their drug-like properties (L24)Ronald T. Borchardt (University of Kansas, USA)14h40-15h10 Coffee break15h10 -15h50From genotype to phenotype in ADMET research (L25)Urs A. 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