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From: "Burke, Ben" <ben.burke ^at^ Agouron.COM>
To: "'Danilo Gonzalez'" <fgonzale ^at^ lauca.usach.cl>, CHEMISTRY ^at^ ccl.net
Subject: RE: Ligand binding to protein (DeltaH=0)
Date: Mon, 12 Mar 2001 15:36:38 -0800

Dear Danilo:
The post from David Turner titled "Protease Inhibitors 
Entropy/Enthalpy" has a number of examples where the 
reaction is entropically driven (but the enthalpy was 
not necessarily equal to 0.00).  It was posted a couple 
of weeks ago (2/27).  The Freire articles outline some 
nice thermodynamic characterization of these systems.
Best to you,
--Ben

---------------------------------------------------------------------- 
Benjamin J. Burke 	 Pfizer Global R&D La Jolla  burke ^%at%^ agouron.com 
Senior Scientist  	 10777 Science Center Dr     Tel (858)622-3018 
Computational Chemistry  San Diego,CA 92121-1111     FAX (858)678-8244


    -----Original Message-----
    From: Danilo Gonzalez [mailto:fgonzale ^%at%^ lauca.usach.cl]
    Sent: Friday, March 02, 2001 8:52 AM
    To: CHEMISTRY %-% at %-% ccl.net
    Subject: CCL:Ligand binding to protein (DeltaH=0)

    I'm looking for references about systems where ligand binding 
    to protein is carried out with Delta H = 0, that is, where the 
    process is Entropically driven.