Andrew: You might try a look at French, Tran, and Perez (Chapter 12, p. 191 in Computer Modeling of Carbohydrate Molecules, ACS Symp. Series #430, A. French and J. Brady, Eds.1990) for a discussion of this problem with MM2 as it relates to disaccharide conformational searches. They modifed MM2 to search each set of angles separately rather than continuously, always beginning from the same starting geometry of each residue. Bruce Pitner pitner[ AT ]bdrc.bd.com