From chemistry-request@server.ccl.net Wed Feb 16 18:21:18 2000 Received: from sdnt1.Acadia-SD (mail.acadia-pharm.com [209.77.18.3]) by server.ccl.net (8.8.7/8.8.7) with ESMTP id SAA31457 for ; Wed, 16 Feb 2000 18:21:17 -0500 Received: by sdnt1 with Internet Mail Service (5.5.2650.21) id <1YA34D1V>; Wed, 16 Feb 2000 14:13:13 -0800 Message-ID: <15189A4705A8D31189B700805F85410B05EADD@sdnt1> From: Daniel Severance To: "'chemistry@ccl.net'" Subject: GPCRs and other non-structural targets Date: Wed, 16 Feb 2000 14:13:12 -0800 MIME-Version: 1.0 X-Mailer: Internet Mail Service (5.5.2650.21) Content-Type: text/plain; charset="iso-8859-1" Hi, Does anyone have a summary of what research groups are working on computational methods for dealing with things where no structures are known? I.e., given the structures of a series of small molecules and their activities, trying to infer something about what interactions must be important? Also, for those of you who may have hired people to work on these kinds of problems - what background have you found is best (assuming they did something different as a student). Thanks. Feel free to e-mail me directly and I'll summarize to the list. Dan ____________________________________________________ Daniel L. Severance Ph.D. phone (858) 558 2871 Computational Chemistry fax (858) 558 2872 ACADIA Pharmaceuticals 3911 Sorrento Valley Boulevard San Diego CA 92121-1402 USA dseverance@acadia-pharm.com www.acadia-pharm.com