From chemistry-request@server.ccl.net Mon Mar 12 18:37:10 2001
Received: from tbone.agouron.com (tbone.agouron.com [198.182.177.3])
	by server.ccl.net (8.11.0/8.11.0) with SMTP id f2CNb9w11916
	for <CHEMISTRY@ccl.net>; Mon, 12 Mar 2001 18:37:09 -0500
Received: from relay.agouron.com by tbone.agouron.com
          via smtpd (for server.ccl.net [192.153.40.39]) with SMTP; 12 Mar 2001 23:37:10 UT
Received: from quarter.agouron.com (quarter.agouron.com [10.0.7.54])
	by dns3.agouron.com (8.9.3/8.9.3) with ESMTP id PAA41129;
	Mon, 12 Mar 2001 15:39:30 -0800 (PST)
Received: by quarter.agouron.com with Internet Mail Service (5.5.2650.21)
	id <GZ5DQV0C>; Mon, 12 Mar 2001 15:36:17 -0800
Message-ID: <074CA135830AD411BA7A00D0B741D25A021FAE55@CAMBIO>
From: "Burke, Ben" <ben.burke@Agouron.COM>
To: "'Danilo Gonzalez'" <fgonzale@lauca.usach.cl>, CHEMISTRY@ccl.net
Subject: RE: Ligand binding to protein (DeltaH=0)
Date: Mon, 12 Mar 2001 15:36:38 -0800

Dear Danilo:
The post from David Turner titled "Protease Inhibitors 
Entropy/Enthalpy" has a number of examples where the 
reaction is entropically driven (but the enthalpy was 
not necessarily equal to 0.00).  It was posted a couple 
of weeks ago (2/27).  The Freire articles outline some 
nice thermodynamic characterization of these systems.
Best to you,
--Ben

---------------------------------------------------------------------- 
Benjamin J. Burke 	 Pfizer Global R&D La Jolla  burke@agouron.com 
Senior Scientist  	 10777 Science Center Dr     Tel (858)622-3018 
Computational Chemistry  San Diego,CA 92121-1111     FAX (858)678-8244


    -----Original Message-----
    From: Danilo Gonzalez [mailto:fgonzale@lauca.usach.cl]
    Sent: Friday, March 02, 2001 8:52 AM
    To: CHEMISTRY@ccl.net
    Subject: CCL:Ligand binding to protein (DeltaH=0)

    I'm looking for references about systems where ligand binding 
    to protein is carried out with Delta H = 0, that is, where the 
    process is Entropically driven.