CCL: MeltDNA: A software to predict of DNA duplex stability.

 Sent to CCL by: "Sunil Kumar Panigahi" [sunil.panigrahi*_*gmail.com]
 Dear All,
 We are releasing the first version of MeltDNA. This can be downloaded from the
 following link.
 http://meltdna.sourceforge.net
                             Overview of the software
                             -------------------------
 Prediction of DNA duplex stability and thermodynamics is invaluable for
 many molecular biology applications involving sequence dependent
 hybridization reactions. Sequence dependent stability of duplex DNA plays
 a major role in fundamental processes of the living cell, such as
 replication,transcription, and recombination. Many techniques in molecular
 biology depend on the oligonucleotide melting temperature (Tm), and
 several formulas have been developed to estimate Tm. We have developed a
 Perl based tool to predict DNA duplex hybridization & melting
 thermo-dynamics.
     This tool consider all factors those determine thermodynamic values
 like-Base composition,NN parameters, salt dependency (Na+, Mg++),
 internal mismatch, dangling ends ,loops etc. For improve NN(nearest
 neighbour) model based calculations we introduced fusion matrices.
 MeltDNA provides better prediction accuracy for DNA duplex
 hybridization especially its ability to handle the structural features
 in DNA duplex like loops, loop size etc. It has got wide applicability
 in primer selection in PCR, probe selection in Microarrays, DNA
 secondary structure stability prediction, DNA computing etc.
 Comments are always welcome to improve the software quality.
 Best Regards,
 Sunil