CCL: query about QMMM interaction energy





Dear All,
I am simulating a protein ligand complex using hybrid QM/MM methods. I want to calculate QM- Interaction energy between QM region and MM region. The output of program gives QMMM electrostatic energy, QMMM bond energy,QMMM bend energy and QMMM torsion energy. Can i use

QM interaction energy = QMMM electrostatic+ QMMM bond +QMMM bend + QMMM torsion

to calculate interaction between QM region and MM region or only QMMM electrostatic energy? If no, then kindly suggest me to calculate such interaction energy

Every help is heartily appreciated. Kindly give me some references related with this methodology.

Thanks in advance.

Regards

Kshatresh Dutta Dubey
Biophysics Unit DDU Gorakhpur University